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Preparation of ellipsoid-shaped supraparticles with modular compositions and investigation of shape-dependent cell-uptake

机译：用模块化组成制备椭球形上浆粒子和形状依赖性细胞摄取的研究

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摘要

Hybrid colloidal supraparticles often show a superior performance in catalysis, optics and biomedicine thanks to the synergistic effect of the ensemble of their single nanoparticle building blocks. Despite the emerging importance of shape-dependent properties of nanostructures, the synthesis of supraparticles is generally limited to a spherical shape. Here, a broadly applicable method is presented for the fabrication of ellipsoid supraparticles from one or several types of inorganic nanoparticles in various compositions. The method is highly versatile and modular, allowing free choice of hydrophobic nanoparticles to combine desired properties in the resulting supraparticles. A representative series of ellipsoid-shaped supraparticles is fabricated and their morphology, hybrid structure and composition as well as their functional properties are investigated. All employed nanoparticle types are successfully incorporated resulting in ellipsoid-shaped supraparticles with largely homogeneous intra-and interparticular distribution of the different nanoparticle building blocks. A biological assessment of iron oxide ellipsoid supraparticles reveals no safety issues but a pronounced lower cellular uptake compared to spherical ones. This distinct shape-property relationship illustrates the importance of the supraparticle shape as a parameter for the rational design of nanosystems for biomedical applications.
机译：由于单一纳米粒子构建块的集合的协同效应，杂交胶体上浆液通常在催化作用，光学和生物医学中显示出卓越的性能。尽管纳米结构的形状依赖性依赖性性质产生了新兴的重要性，但是制备的合成通常限于球形。这里，提出了一种广泛适用的方法，用于在各种组合物中从一种或几种类型的无机纳米颗粒制造椭圆体上皮粒子。该方法具有高通用和模块化，允许自由选择疏水纳米颗粒以将所得的上浆粒子中的所需性质结合在一起。研究了代表性的椭圆形上浆粒子，并研究了它们的形态，杂化结构和组成以及它们的功能性。成功地掺入所有使用的纳米颗粒类型，得到椭圆形上颗粒的不同纳米粒子构建块的基本均匀均匀的内部分布。氧化铁椭圆体上皮粒子的生物学评估显示出与球形胶片相比的明显下细胞摄取的安全问题。这种不同的形状 - 性质关系说明了上叠片形状作为用于生物医学应用纳米系统的合理设计的参数的参数。

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  • 来源
    《RSC Advances》 |2016年第92期|共12页
  • 作者

    Ulrich S.; Hirsch C.; Diener L.; Wick P.; Rossi R. M.; Bannwarth M. B.; Boesel L. F.;

  • 作者单位

    Swiss Fed Labs Mat Sci &

    Technol Empa Lab Protect &

    Physiol Lerchenfeldstr 5 CH-9014 St Gallen Switzerland;

    Swiss Fed Labs Mat Sci &

    Technol Empa Particle Biol Interact Lab Lerchenfeldstr 5 CH-9014 St Gallen Switzerland;

    Swiss Fed Labs Mat Sci &

    Technol Empa Particle Biol Interact Lab Lerchenfeldstr 5 CH-9014 St Gallen Switzerland;

    Swiss Fed Labs Mat Sci &

    Technol Empa Particle Biol Interact Lab Lerchenfeldstr 5 CH-9014 St Gallen Switzerland;

    Swiss Fed Labs Mat Sci &

    Technol Empa Lab Protect &

    Physiol Lerchenfeldstr 5 CH-9014 St Gallen Switzerland;

    Swiss Fed Labs Mat Sci &

    Technol Empa Lab Protect &

    Physiol Lerchenfeldstr 5 CH-9014 St Gallen Switzerland;

    Swiss Fed Labs Mat Sci &

    Technol Empa Lab Protect &

    Physiol Lerchenfeldstr 5 CH-9014 St Gallen Switzerland;

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  • 正文语种 eng
  • 中图分类 化学;
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