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首页> 外文期刊>RSC Advances >Design and development of a nanoemulsion system containing copper peptide by D-optimal mixture design and evaluation of its physicochemical properties
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Design and development of a nanoemulsion system containing copper peptide by D-optimal mixture design and evaluation of its physicochemical properties

机译：D-最优混合物设计及其物理化学性质评价含铜肽含铜肽的纳米乳液系统的设计与发展

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Copper peptide is an important compound used to prevent ageing; a process that leads to several unwanted aging signs such as wrinkles, sagging, pigmented spots and dryness. The D-optimal mixture design was used for optimizing the particle size of Virgin Coconut Oil (VCO) nanoemulsions for topical delivery of copper peptide. Effects of formulation variables including VCO (10-20%, w/w), Tween 80 : Pluronic PF68 (10-15%, w/w), xanthan gum (0.5-1.0%, w/w) and water (64.008-79.291), towards particle size as a response were studied. D-optimal mixture design analysis demonstrated that the variation in particle size as a response could be expressed as a quadratic function of the main components of the emulsion. Analysis of variance (ANOVA) showed that the quadratic polynomial model sufficiently fits the experimental data. The best combination of the composition factors that gave the optimum particle size was found to be VCO (10%, w/w), T80 : PF68 (15%, w/w), xanthan gum (0.867%, w/w) and water (74.133%, w/w). Under these optimum compositions, the actual particle size showed good agreement with predicted particle size with a residual standard error (RSE) less than 2%. The formulation containing copper peptide was successfully prepared with a particle size value of 120.7 nm, which was consistent with the result obtained by TEM. The final formulation also showed good conductivity and pH values as well as stability against phase separation. A rheology study demonstrates that the VCO nanoemulsion containing copper peptide exhibited shear thinning and pseudoplastic properties and showed more elastic rather than viscous characteristics due to the presence of a large linear viscoelastic region. Permeability test results showed that copper peptide in aqueous solution with and without penetration enhancer cannot be transported through the cellulose acetate membrane after 8 h application. The nanoemulsion increased the permeability of copper peptide with 21.89 +/- 0.53% active matter release after 8 h application.
机译：铜肽是用于防止老化的重要化合物;一个过程，导致不希望的几个迹象老化如皱纹，下垂，色素斑和干燥。用于优化初榨椰子油（VCO）的纳米乳剂的粒径为铜肽的局部递送的d-最佳混合物的设计。配方变量的影响，包括VCO（10-20％，重量/重量），吐温80：普朗尼克PF68（10-15％，重量/重量），黄原胶（0.5-1.0％，重量/重量）和水（64.008- 79.291），朝粒径作为响应进行了研究。 d-最佳混合物设计分析表明，作为响应在颗粒尺寸的变化可以表示为乳液​​的主要成分的二次函数。 （ANOVA）显示方差分析的二次多项式模型拟合足够的实验数据。这给了最佳粒度组成因素的最佳组合被发现是VCO（10％，重量/重量），T80：PF68（15％，重量/重量），黄原胶（0.867％，W / W）和水（74.133％，重量/重量）。在这些最佳组合物中，实际粒径显示出与预测的颗粒尺寸小于2％的良好协议具有残余标准误差（RSE）。含配制剂铜肽成功地与的120.7纳米的粒径值，这与通过TEM获得的结果是一致的制备。最终的制剂也表现出良好的电导率和pH值，以及针对相分离的稳定性。流变研究表明，含有铜的纳米乳剂VCO肽显示的剪切稀化和假塑性特性和由于大的线性粘弹性区域的存在表现出更多的弹性，而不是粘性的特性。渗透性试验结果表明在水溶液中铜肽具有和不渗透增强剂无法通过醋酸纤维素膜后8小时的应用程序进行传输。所述纳米乳剂后8小时应用与21.89 +/- 0.53％的活性物质释放增加铜肽的渗透性。

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  • 来源
    《RSC Advances》 |2016年第22期|共12页
  • 作者

    Samson Shazwani; Basri Mahiran; Masoumi Hamid Reza Fard; Karjiban Roghayeh Abedi; Malek Emilia Abdul;

  • 作者单位

    Univ Putra Malaysia Fac Sci Dept Chem Upm Serdang 43400 Selangor Malaysia;

    Univ Putra Malaysia Fac Sci Dept Chem Upm Serdang 43400 Selangor Malaysia;

    Univ Putra Malaysia Fac Sci Dept Chem Upm Serdang 43400 Selangor Malaysia;

    Univ Putra Malaysia Fac Sci Dept Chem Upm Serdang 43400 Selangor Malaysia;

    Univ Putra Malaysia Fac Sci Dept Chem Upm Serdang 43400 Selangor Malaysia;

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  • 正文语种 eng
  • 中图分类 化学;
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