首页> 外文期刊>RSC Advances >Facile synthesis and characterization of beta lactoglobulin-copper nanocomposites having antibacterial applications
【24h】

Facile synthesis and characterization of beta lactoglobulin-copper nanocomposites having antibacterial applications

机译:β乳酰脱蛋白 - 铜纳米复合材料的容易合成与表征,具有抗菌应用

获取原文
获取原文并翻译 | 示例
           

摘要

The synthesis of Cu-0 nanoparticles and Cu-protein nanocomposites is a great challenge. Here we describe a simple and convenient method for the synthesis of Cu-beta-lactoglobulin nanocomposites using very cheap CuSO4 center dot 5H(2)O and the retinol binding model protein bovine beta-lactoglobulin (beta-lg) at pH 10.0 in ammoniacal medium. Then addition of hydrazine hydrates in the reaction mixture and heating the solution at 55 degrees C for 2 h resulted in the formation of hexagonal Cu-beta-lg nanocomposite (average size 0.5 mu m) containing the embedded Cu-nanoparticles as revealed from SEM and TEM analysis. The important feature of this method is that the highly stable Cu-nanoparticle present in the composites were synthesized without employing any inert atmosphere; decomposition of hydrazine hydrate generated the nitrogen in situ which produced the inert atmosphere for this reaction. Synthesis of this nanocomposite is justified by a docking study. The synthesized nanocomposite exhibits potential antibacterial activity against both Gram positive and Gram negative bacterial strains. Thus it can be employed in different medical applications and also in the preparation of various nanomedicines.
机译:Cu-0纳米颗粒和Cu-蛋白纳米复合材料的合成是一个很大的挑战。在这里,我们描述了使用非常廉价的CuSO4中心点5H(2)O和在氨基培养基中的pH1.10.0处的视黄醇结合模型蛋白牛β-乳酰粘蛋白(Beta-Lg)来合成Cu-β-乳酰叶蛋白纳米复合材料的简单而方便的方法。然后在反应混合物中加入水合物,并在55℃下加热溶液2小时导致含有嵌入式Cu-Nanim颗粒的六边形Cu-β-Lg纳米复合材料(平均尺寸0.5μm),含有来自SEM和TEM分析。该方法的重要特征是合成复合材料中存在的高度稳定的Cu纳米颗粒而不采用任何惰性气氛;肼水合物的分解产生氮原位,其为该反应产生惰性气氛。该纳米复合材料的合成通过对接研究是合理的。合成的纳米复合材料对革兰氏阳性和革兰氏阴性细菌菌株表现出潜在的抗菌活性。因此,它可以在不同的医学应用中使用,并且还可以在制备各种纳米内胺中。

著录项

  • 来源
    《RSC Advances》 |2016年第88期|共7页
  • 作者单位

    Jadavpur Univ Dept Chem Kolkata 700032 India;

    Jadavpur Univ Dept Chem Kolkata 700032 India;

    Jadavpur Univ Dept Chem Kolkata 700032 India;

    Jadavpur Univ Dept Chem Kolkata 700032 India;

    Durgapur Govt Coll Dept Chem Durgapur 713214 W Bengal India;

    Jadavpur Univ Dept Chem Kolkata 700032 India;

    Jadavpur Univ Dept Phys Kolkata 700032 India;

    Jadavpur Univ Dept Chem Kolkata 700032 India;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号