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Antimicrobial activities of phosphonium containing polynorbornenes

机译：含膦酸鏻的抗微生物活性

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摘要

In this study, amphiphilic polyoxanorbornene with different alkyl and aromatic phosphonium side chains was synthesized. The biological activities of these polymers were determined by the minimal inhibitory concentration (MIC) against E. coli, S. aureus, M. tuberculosis and the yeast C. albicans, and cytotoxicity studies on red blood cells were performed. A series of polymers with different alkyl and aromatic substituents (methyl, ethyl, tripropyl, tert-butyl, phenyl, and tris 4-methoxyphenyl) and two types different molecular weight, 3000 g mol(-1) and 10 000 g mol(-1), were prepared. It was observed that the biological activity of the polymers with aromatic group substituents had an MIC of 16, 8, 64 and 128 mu g mL(-1) against E. coli, S. aureus, M. tuberculosis and C. albicans, respectively, while those with nonaromatic carbons had a higher MIC compared to those with aromatic carbons. The aromaticity of the repeat unit had impressive effects on hemolytic activities as well. Zeta potential measurements of E. coli incubated with active and inactive polymer concentration revealed a relationship between the MIC and membrane surface charge density. Polymers bearing aromatic groups killed the bacteria with widespread damage after the polymers, holding the threshold concentration, were added to the bacteria.
机译：在该研究中，合成了具有不同烷基和芳族鏻侧链的两亲多硅叶植物。这些聚合物的生物活性通过对阵大肠杆菌的最小抑制浓度（MIC）测定，S. aureus，M.结核和酵母C.古木儿，并且进行了对红细胞的细胞毒性研究。一系列具有不同烷基和芳族取代基的聚合物（甲基，乙基，三丙基，叔丁基，苯基和三甲氧基苯基）和两种类型的不同分子量，3000g摩尔（-1）和10 000g摩尔（ - 1），制备。观察到具有芳族基团的聚合物的生物活性分别具有16,8,64和128μmgml（-1）的MIC，分别对抗大肠杆菌，金黄色葡萄球菌和染色剂。而且与含有芳香碳的人相比，含有非芳族碳的人具有更高的MIC。重复单元的芳香性也对溶血活动产生了令人印象深刻的影响。与活性和无活性聚合物浓度温育的大肠杆菌的Zeta电位测量显示了MIC和膜表面电荷密度之间的关系。将芳香族含有芳族基团的聚合物在细菌中加入阈值浓度之后具有广泛的损伤的细菌。

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  • 来源
    《RSC Advances》 |2016年第89期|共7页
  • 作者

    Suer N. Ceren; Demir Ceren; Unubol Nihan A.; Yalcin Ozlem; Kocagoz Tanil; Eren Tarik;

  • 作者单位

    Yildiz Tech Univ Dept Chem Davutpasa Campus TR-34220 Istanbul Turkey;

    Yildiz Tech Univ Dept Chem Davutpasa Campus TR-34220 Istanbul Turkey;

    Acibadem Univ Dept Med Microbiol Kerem Aydinlar Campus TR-34752 Istanbul Turkey;

    Koc Univ Sch Med Sariyer Campus TR-34450 Istanbul Turkey;

    Acibadem Univ Dept Med Microbiol Kerem Aydinlar Campus TR-34752 Istanbul Turkey;

    Yildiz Tech Univ Dept Chem Davutpasa Campus TR-34220 Istanbul Turkey;

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  • 正文语种 eng
  • 中图分类 化学;
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