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Synthesis and characterization of PLGA nanoparticle/4-arm-PEG hybrid hydrogels with controlled porous structures

机译：PLGA纳米粒子/ 4臂 - PEG杂交水凝胶的合成与表征，具有受控多孔结构

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摘要

Controlled porous structures, adjustable surface properties and good mechanical properties are essential for hydrogels in promoting cell adhesion and growth. In this work, we developed four armed poly(ethylene glycol) (4-arm-PEG) hydrogels crosslinked by poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs). Branched polyethyleneimine (b-PEI) was employed for aminolysis of PLGA to engineer 300, 530 and 1000 nm NPs with a nitrogen contents of 11.7%, 9.4% and 9.7%. Hybrid hydrogels were formed by crosslinking amino-packed NPs with polymeric chains of 4-arm-PEG-NHS. By manipulating the NP and PEG contents as well as the NP sizes, the pore sizes could be tailored from 10-20 mu m to 20-40 mu m and 100-200 mu m, and the maximal compressive strength could be optimized to 0.37 MPa. Cytotoxicity trials indicated the hydrogels were almost non-toxic and biocompatible. Cell adhesion evaluation testified higher amino contents and a smaller proportion of PEG led to more cell attachment. These results demonstrated that this kind of hybrid hydrogel may be a suitable candidate for further biomedical applications in tissue engineering.
机译：受控多孔结构，可调节表面性能和良好的机械性能对于促进细胞粘附和生长的水凝胶是必需的。在这项工作中，我们开发了由聚（乳酸 - 共乙醇酸）纳米颗粒（PLGA NPS）交联的四个武装聚（乙二醇）（4-ARM-PEG）水凝胶。支化聚乙烯亚胺（B-PEI）用于氨基溶于工程师300,530和1000nm的NPS，氮含量为11.7％，9.4％和9.7％。通过将氨基填充的NPS与4臂 - PEG-NHS的聚合物链交联形成杂种水凝胶。通过操纵NP和PEG含量以及NP尺寸，可以根据10-20μm至20-40μm和100-200μm来定制孔径，并且最大抗压强度可以优化至0.37MPa 。细胞毒性试验表明水凝胶几乎是无毒和生物相容性的。细胞粘附评估验证较高的氨基含量，较小的PEG比例导致更多的细胞附着。这些结果表明，这种杂种水凝胶可以是用于组织工程中进一步生物医学应用的合适候选者。

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  • 来源
    《RSC Advances》 |2016年第59期|共9页
  • 作者

    Zhuang Yaping; Shen Hong; Yang Fei; Wang Xing; Wu Decheng;

  • 作者单位

    Chinese Acad Sci Inst Chem State Key Lab Polymer Phys &

    Chem Beijing Natl Lab Mol Sci Beijing 100190 Peoples R China;

    Chinese Acad Sci Inst Chem State Key Lab Polymer Phys &

    Chem Beijing Natl Lab Mol Sci Beijing 100190 Peoples R China;

    Chinese Acad Sci Inst Chem State Key Lab Polymer Phys &

    Chem Beijing Natl Lab Mol Sci Beijing 100190 Peoples R China;

    Chinese Acad Sci Inst Chem State Key Lab Polymer Phys &

    Chem Beijing Natl Lab Mol Sci Beijing 100190 Peoples R China;

    Chinese Acad Sci Inst Chem State Key Lab Polymer Phys &

    Chem Beijing Natl Lab Mol Sci Beijing 100190 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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