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首页> 外文期刊>RSC Advances >Punica granatum (pomegranate) peel extract exerts potent antitumor and anti-metastasis activity in thyroid cancer
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Punica granatum (pomegranate) peel extract exerts potent antitumor and anti-metastasis activity in thyroid cancer

机译：Punica Granatum（石榴）剥皮提取物在甲状腺癌中施加有效的抗肿瘤和抗转移活性

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摘要

The incidence of thyroid carcinoma has obviously been rising throughout the world during the past ten years. However, over-treatment has usually occurred in thyroid carcinoma without new and effective approaches being explored. In this study, Punica granatum (pomegranate) peel extract (PoPx), a kind of herb, was evaluated for its anticancer activity to thyroid carcinoma in vitro and in vivo. PoPx potently suppressed proliferation in two kinds of thyroid cancer cell lines, and induced cancer cell apoptosis. PoPx could also decrease the mitochondrial membrane potential (Delta Psi(m)), indicating that PoPx may induce apoptosis via a mitochondria-mediated apoptotic pathway. In addition, PoPx markedly impaired thyroid cancer cell migration and invasion by down-regulating the expression of matrix metalloproteinase-9 (MMP-9). More importantly, PoPx significantly inhibited tumor growth in the BCPAP-bearing mice model by reducing cell proliferation and inducing apoptosis. These findings suggest that PoPx could be an effective phytochemical agent.
机译：在过去的十年中，甲状腺癌的发生率显然在全世界都在崛起。然而，过治疗通常发生在甲状腺癌中，而无需探索新的和有效的方法。在本研究中，Punica Granatum（石榴）剥皮提取物（Popx），一种草本植物在体外和体内评估其抗癌活性对甲状腺癌。 Popx在两种甲状腺癌细胞系中有效地抑制了增殖，并诱导癌细胞凋亡。 Popx还可以降低线粒体膜电位（Delta psi（m）），表明popx可以通过线粒体介导的凋亡途径诱导细胞凋亡。此外，POPX通过下调基质金属蛋白酶-9（MMP-9）的表达明显受损的甲状腺癌细胞迁移和侵袭。更重要的是，Popx通过降低细胞增殖和诱导细胞凋亡，Popx显着抑制了含有BCPAP造成的小鼠模型中的肿瘤生长。这些发现表明popx可以是有效的植物化学药剂。

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  • 来源
    《RSC Advances》 |2016年第87期|共13页
  • 作者

    Li Yujue; Ye Tinghong; Yang Fangfang; Hu Mingxing; Liang Libo; He He; Li Zhipeng; Zeng Anqi; Li Yali; Yao Yuqin; Xie Yongmei; An Zhenmei; Li Shuangqing;

  • 作者单位

    Sichuan Univ West China Hosp Dept Gen Practice Med Dept Endocrinol &

    Metab Chengdu Peoples R China;

    Sichuan Univ West China Hosp State Key Lab Biotherapy Chengdu Peoples R China;

    Sichuan Univ West China Hosp State Key Lab Biotherapy Chengdu Peoples R China;

    Sichuan Univ West China Hosp State Key Lab Biotherapy Chengdu Peoples R China;

    Sichuan Univ West China Hosp Dept Gen Practice Med Dept Endocrinol &

    Metab Chengdu Peoples R China;

    Sichuan Univ West China Hosp Dept Lab Med Chengdu Peoples R China;

    Sichuan Univ West China Hosp Dept Gen Practice Med Dept Endocrinol &

    Metab Chengdu Peoples R China;

    Sichuan Univ West China Hosp State Key Lab Biotherapy Chengdu Peoples R China;

    Sichuan Univ West China Hosp State Key Lab Biotherapy Chengdu Peoples R China;

    Sichuan Univ West China Hosp State Key Lab Biotherapy Chengdu Peoples R China;

    Sichuan Univ West China Hosp State Key Lab Biotherapy Chengdu Peoples R China;

    Sichuan Univ West China Hosp Dept Gen Practice Med Dept Endocrinol &

    Metab Chengdu Peoples R China;

    Sichuan Univ West China Hosp Dept Gen Practice Med Dept Endocrinol &

    Metab Chengdu Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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