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首页> 外文期刊>RSC Advances >A facile approach to upconversion crystalline CaF2:Yb3+,Tm3+@mSiO(2) nanospheres for tumor therapy
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A facile approach to upconversion crystalline CaF2:Yb3+,Tm3+@mSiO(2) nanospheres for tumor therapy

机译：用于上转化结晶CAF2：YB3 +，TM3 + @ MSIO（2）纳米球的肿瘤治疗方法

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摘要

A new facile approach, namely chemical-assisted sol-gel growth (CASGG), was successfully developed to induce the formation of fine CaF2:Yb3+,Tm3+ nanocrystals within the pore channels of mesoporous silica (mSiO(2)) nanoparticles. A series of upconversion photoluminescent crystalline CaF2:Yb3+,Tm3+@mSiO(2) nanospheres with controlled diameters from similar to 65 nm to similar to 290 nm were fabricated. All nanospheres presented sound cyto-compatibility and unique ratiometric spectral monitoring functionalities for drug release kinetics. The nanospheres with smallest dimension (UCNP-2.5, similar to 65 nm) induced the most sustained DOX release kinetics. More importantly, the in vitro study demonstrated that the DOX loaded UCNP-2.5 nanospheres presented the strongest anti-cancer efficacy to MCF-7 human breast cancer cells due to its stronger penetration ability to cell nuclei due to the size effect.
机译：成功开发了一种新的容纳方法，即化学辅助溶胶 - 凝胶生长（CASGG），以诱导介孔二氧化硅（MSIO（2））纳米粒子的孔通道内的细CAF2：YB3 +，TM3 +纳米晶体的形成。 制造了一系列上转换的光致发光结晶Caf2：Yb3 +，TM3 + @ MSIO（2）纳米球，其具有与65nm相似的受控直径与类似于290nm的直径。 所有纳米球都呈现出声释放动力学的声音细胞兼容性和独特的比例光谱监测功能。 具有最小尺寸的纳米球（UCNP-2.5，类似于65nm）诱导最持续的DOX释放动力学。 更重要的是，体外研究表明，由于尺寸效应，DOX负载的UCNP-2.5纳米球体呈现出对MCF-7人乳腺癌细胞的最强的抗癌疗效。

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  • 来源
    《RSC Advances》 |2016年第44期|共6页
  • 作者

    Li Yangyang; Zhou Yurong; Li Xiang; Sun Jihong; Ren Zhaohui; Wen Wengjian; Yang Xiaoming; Han Gaorong;

  • 作者单位

    Zhejiang Univ Sch Mat Sci &

    Engn State Key Lab Silicon Mat Hangzhou 310027 Zhejiang Peoples R China;

    Zhejiang Univ Sir Run Run Shaw Hosp Dept Radiol Sch Med Hangzhou 310016 Zhejiang Peoples R China;

    Zhejiang Univ Sch Mat Sci &

    Engn State Key Lab Silicon Mat Hangzhou 310027 Zhejiang Peoples R China;

    Zhejiang Univ Sir Run Run Shaw Hosp Dept Radiol Sch Med Hangzhou 310016 Zhejiang Peoples R China;

    Zhejiang Univ Sch Mat Sci &

    Engn State Key Lab Silicon Mat Hangzhou 310027 Zhejiang Peoples R China;

    Zhejiang Univ Sch Mat Sci &

    Engn State Key Lab Silicon Mat Hangzhou 310027 Zhejiang Peoples R China;

    Zhejiang Univ Sir Run Run Shaw Hosp Dept Radiol Sch Med Hangzhou 310016 Zhejiang Peoples R China;

    Zhejiang Univ Sch Mat Sci &

    Engn State Key Lab Silicon Mat Hangzhou 310027 Zhejiang Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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