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Injectable and self-healing dynamic hydrogel containing bioactive glass nanoparticles as a potential biomaterial for bone regeneration

机译：含有生物活性玻璃纳米粒子的可注射和自愈的动态水凝胶作为骨再生的潜在生物材料

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摘要

Combination of an Au-based 4-arms thiol terminated poly(ethylene glycol) [Au-(PEGSH)(4)] dynamic hydrogel exhibiting self-healing ability with 100 nm bioactive glass (BAG) nanoparticles agglomerated in 10 mm clusters, produced via a particulate sol-gel method, resulted in the formation of hydrogel nanocomposites [Au-(PEGSH)(4)-BAG] with enhanced properties. Au-(PEGSH)(4)-BAG hydrogel nanocomposites were prepared by injecting simultaneously an aqueous solution of a (PEGSH)(4) homopolymer containing different amounts of BAG nanoparticles with an aqueous solution of HAuCl4 using a double barrel syringe. Electron microscopy studies suggested that the clusters of inorganic particles were homogeneously distributed into the polymeric matrix. Rheology studies demonstrated that stiffer hydrogels were obtained after the addition of BAG nanoparticles. The presence of the inorganic colloids appeared to affect slightly the dynamic character of the pristine hydrogel by slowing down the exchange reaction between gold-thiolate (Au-S) and disulfides (SS). Despite slower Au-S/SS exchange, the resulting hydrogel nanocomposites were still exhibiting pH-dependent properties and self-healing abilities, as judged by frequency sweep experiments. In addition, compression tests demonstrated the major drawbacks of each individual material, i.e. brittleness for BAG nanoparticles and weak consistency for Au-(PEGSH)(4), were suppressed to result in a material composite with high resistance to stress and relatively large deformation ability. Moreover, the slow diffusion inside the 3D matrix allowed the degradation of the BAG nanoparticles to be delayed as well as the pH to be maintained around physiological values. For the same reason, the incorporation of those BAG nanoparticles into the dynamic hydrogel proved to reduce the cytotoxicity of the organic particles. Finally, in vitro degradation of BAG nanoparticles embedded in the dynamic hydrogel led to the formation of hydroxyapatite. As a result, osteoinductive properties could be anticipated for the Au-(PEGSH)(4)-BAG hydrogel nanocomposite which allows this new injectable and self-healing dynamic biomaterial to be considered as a scaffold to induce and promote bone self-repair.
机译：基于Au的4臂硫醇终止聚（乙二醇）[Au-（Pegsh）（4）]动态水凝胶，其具有100nm生物活性玻璃（袋）纳米颗粒在10mM簇中凝聚的自愈合能力，产生通过一种颗粒状溶胶 - 凝胶方法，导致水凝胶纳米复合材料[Au-（Pegsh）（4）-bag]具有增强性质。通过同时注射（PEGSH）（4）均聚物的含水溶液来制备AU-（PEGSH）（4）-BAG水凝胶纳米复合材料，所述含有不同量的袋纳米颗粒，所述袋纳米粒子用HauCl4水溶液使用双筒注射器来制备。电子显微镜研究表明，无机颗粒的簇均匀地分布到聚合物基质中。流变学研究表明，在加入袋纳米颗粒后获得了纤巧的水凝胶。通过减慢金子硫醇酯（AU-S）和二硫化物（SS）之间的交换反应，似乎无机胶体的存在略微影响原始水凝胶的动态特征。尽管AU-S / SS交换较慢，所得水凝胶纳米复合材料仍然表现出pH依赖性性质和自我愈合能力，通过频率扫描实验判断。此外，压缩试验证明了每个单独材料的主要缺点，即袋纳米粒子的脆性和Au-（Pegsh）（4）的弱稠度，以导致具有高抗应力和相对大的变形能力的材料复合材料。此外，3D基质内的缓慢扩散允许袋纳米颗粒的劣化延迟以及待维持在生理值的pH。出于同样的原因，将这些袋子纳米颗粒掺入动态水凝胶中证明是为了减少有机颗粒的细胞毒性。最后，在动态水凝胶中嵌入动态水凝胶中的袋纳米粒子的体外降解导致形成羟基磷灰石。结果，可以预期骨诱导性能的Au-（PEGSH）（4）-Bag水凝胶纳米复合材料，其允许这种新的可注射和自愈的动态生物材料被认为是诱导和促进骨骼自我修复的支架。

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  • 来源
    《RSC Advances》 |2016年第73期|共11页
  • 作者

    Gantar Ana; Drnovsek Natasa; Casuso Pablo; Perez-San Vicente Adrian; Rodriguez Javier; Dupin Damien; Novak Sasa; Loinaz Iraida;

  • 作者单位

    Jozef Stefan Inst Dept Nanostruct Mat Ljubljana Slovenia;

    Jozef Stefan Inst Dept Nanostruct Mat Ljubljana Slovenia;

    IK4 CIDETEC Res Ctr Div Mat Paseo Miramon 196 Donostia San Sebastian 20009 Spain;

    IK4 CIDETEC Res Ctr Div Mat Paseo Miramon 196 Donostia San Sebastian 20009 Spain;

    IK4 CIDETEC Res Ctr Div Mat Paseo Miramon 196 Donostia San Sebastian 20009 Spain;

    IK4 CIDETEC Res Ctr Div Mat Paseo Miramon 196 Donostia San Sebastian 20009 Spain;

    Jozef Stefan Inst Dept Nanostruct Mat Ljubljana Slovenia;

    IK4 CIDETEC Res Ctr Div Mat Paseo Miramon 196 Donostia San Sebastian 20009 Spain;

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  • 正文语种 eng
  • 中图分类 化学;
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