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首页> 外文期刊>RSC Advances >Folic acid targeted pH-responsive amphiphilic polymer nanoparticles conjugated with near infrared fluorescence probe for imaging-guided drug delivery
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Folic acid targeted pH-responsive amphiphilic polymer nanoparticles conjugated with near infrared fluorescence probe for imaging-guided drug delivery

机译：叶酸靶向pH-响应式两亲聚合物纳米颗粒与近红外荧光探针缀合用于显影引导的药物递送

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摘要

A novel folic acid targeted pH-responsive amphiphilic polymer conjugated with near infrared (NIR) probe has been synthesized by the combination of reversible addition-fragmentation chain transfer (RAFT) polymerization of 2-(N-tert-butoxycarbonylamino)ethyl methacrylate (BEMA) and oligo(ethylene glycol) methacrylate (OEGMA), ring-opening polymerization of N-carboxy anhydride (NCA) and click reaction. After assembling to micelles, the polymeric nanoparticles has pH-responsive properties for delivery encapsulated drug into the tumor cell via a rapid process of expansion and subsequent disassembly. Folic acid linked to the amino groups on the branched chains would promote the endocytosis of the polymeric nanoparticles by the cells leading the improvement of the effect of doxorubicin (DOX). In vitro experiments on both MCF7 and HepG2 cells revealed the as-prepared polymer might be a potential candidate for future theranosic against cancer.
机译：通过2-（N-叔丁氧基羰基氨基）乙基丙烯酸乙酯（BEMA）的可逆添加 - 碎片链转移（筏）聚合的组合，合成了与近红外（NIR）探针缀合的新型叶酸靶向pH-响应两亲性聚合物。（N-叔丁氧基羰基氨基）乙基丙烯酸乙酯（BEMA） 和寡核苷酸（乙二醇）甲基丙烯酸酯（OEGMA），N-羧酸酐（NCA）的开环聚合，并点击反应。 在组装到胶束后，聚合物纳米颗粒通过快速膨胀和随后的拆卸过程具有pH-响应性用于将包封的药物输送到肿瘤细胞中。 连接到支链上的氨基上的叶酸将通过细胞促进聚合物纳米颗粒的内吞作用，这导致改善多柔比星（DOX）的作用。 在MCF7和HEPG2细胞上的体外实验揭示了AS制备的聚合物可能是未来治疗癌症的潜在候选者。

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  • 来源
    《RSC Advances》 |2016年第46期|共11页
  • 作者

    Fu Liyi; Liu Le; Ruan Zheng; Zhang Houbing; Yan Lifeng;

  • 作者单位

    Univ Sci &

    Technol China iChEM Hefei Natl Lab Phys Sci Microscale CAS Key Lab Soft Matter Chem Jinzai Rd 96 Hefei 230026 Anhui Peoples R China;

    Univ Sci &

    Technol China iChEM Hefei Natl Lab Phys Sci Microscale CAS Key Lab Soft Matter Chem Jinzai Rd 96 Hefei 230026 Anhui Peoples R China;

    Univ Sci &

    Technol China iChEM Hefei Natl Lab Phys Sci Microscale CAS Key Lab Soft Matter Chem Jinzai Rd 96 Hefei 230026 Anhui Peoples R China;

    Univ Sci &

    Technol China iChEM Hefei Natl Lab Phys Sci Microscale CAS Key Lab Soft Matter Chem Jinzai Rd 96 Hefei 230026 Anhui Peoples R China;

    Univ Sci &

    Technol China iChEM Hefei Natl Lab Phys Sci Microscale CAS Key Lab Soft Matter Chem Jinzai Rd 96 Hefei 230026 Anhui Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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