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Janus films with stretchable and waterproof properties for wound care and drug delivery applications

机译：Janus薄膜具有可伸缩和防水性能的伤口护理和药物递送应用

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摘要

A commercial bandage provides a quick solution to small cuts and bruises by absorbing excess blood and covering the wound. In this study, we propose a type of medical dressing using a polydimethylsiloxane (PDMS) membrane with significant potential to improve wound healing conditions. A thin soft Janus PDMS film with opposing porous and nonporous faces is fabricated and tested for qualities applicable to improve current bandages, such as the porosity, stretchability, and water-wettability. The PDMS film can be stretched to 150% of its original length to allow the bending of fingers or joints. The nonporous face of the PDMS film provides a natural waterproofing barrier against intrusion by microbes and contaminants. The porous face of the bandage with pore size between 100 mm and 400 mm provides abundant void space for the preloading of pharmaceuticals and allows a relatively quick drug release (over 50% in 5 min, over 80% in 30 min), while simultaneously improving water vapor permeability. Blood absorbed could be distributed within the film's pore network, reducing the chances of forming a large clot and hardened scab that may break the wound bed upon removal. All these improvements demonstrate that the Janus PDMS film will provide the performance needs as a new bandage for wound care.
机译：商用绷带通过吸收多余的血液并覆盖伤口，为小型切割和瘀伤提供快速解决方案。在这项研究中，我们提出了一种使用聚二甲基硅氧烷（PDMS）膜的药物敷料，其具有显着的潜力来改善伤口愈合条件。制造和测试具有相对的多孔和无孔面的薄软janus pdms薄膜，并测试适用于改善电流绷带的品质，例如孔隙率，拉伸性和水润湿性。 PDMS膜可以拉伸到其原始长度的150％以允许弯曲手指或接头。 PDMS薄膜的无孔面为微生物和污染物的侵扰自然防水屏障。毛绷带的多孔面，孔径为100mm和400mm，为药物预加载提供了丰富的空隙空间，并允许相对较快的药物释放（5分钟超过50％，在30分钟内超过80％），同时改善水蒸气渗透性。吸收的血液可以分布在薄膜的孔网络内，减少形成大凝块和硬化结痂的机会，该机会可以在去除后破坏伤口床。所有这些改进都表明Janus PDMS电影将提供性能需求作为伤口护理的新绷带。

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  • 来源
    《RSC Advances》 |2016年第83期|共10页
  • 作者

    Lee Ethan; Zhang Hongbin; Jackson John K.; Lim Chinten James; Chiao Mu;

  • 作者单位

    Univ British Columbia Dept Mech Engn Vancouver BC V6T 1Z4 Canada;

    Univ British Columbia Dept Mech Engn Vancouver BC V6T 1Z4 Canada;

    Univ British Columbia Dept Pharmaceut Sci Vancouver BC V6T 1Z4 Canada;

    Univ British Columbia Child &

    Family Res Inst Dept Pediat Vancouver BC V5Z 4H4 Canada;

    Univ British Columbia Dept Mech Engn Vancouver BC V6T 1Z4 Canada;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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