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首页> 外文期刊>RSC Advances >Polymer-grafted superparamagnetic iron oxide nanoparticles as a potential stable system for magnetic resonance imaging and doxorubicin delivery
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Polymer-grafted superparamagnetic iron oxide nanoparticles as a potential stable system for magnetic resonance imaging and doxorubicin delivery

机译：聚合物接枝的超顺磁性氧化铁纳米粒子作为磁共振成像和多柔比星输送的潜在稳定系统

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摘要

Currently, there is high interest in developing multifunctional theranostic platforms with both imaging and therapeutic functions. Herein, we report a facile approach to develop polymer-grafted superparamagnetic iron oxide nanoparticles (SPIONs) as a promising system for imaging and drug delivery. A random copolymer composed of pendant-activated ester moieties, that is, pentafluorophenyl acrylate (PFPA) and polyethylene glycol monomethyl ether methacrylate (PEGMA), were synthesized and grafted on SPION surfaces using the click reaction. The resultant multifunctional SPIONs were characterized using FT-IR, XRD, XPS, TGA and TEM, proving the presence of polymers on their surfaces. The formed polymergrafted SPIONs are water-dispersible, stable, and biocompatible as confirmed by a cell viability assay. Relaxivity measurements show that they have a T-2* relaxivity (r(2)*) of 134.40 mM(-1) S-1, which is higher than the value obtained from the commercial FDA approved MRI contrast agent Ferumoxytol (85 mM(-1) S-1). Furthermore, doxorubicin (DOX) was loaded onto the polymeric shell of modified SPIONs and exhibited fast drug release in response to acidic conditions (pH 5.4). These results clearly indicate that the prepared modified SPIONs have great potential to serve as a multifunctional nanosystem for T(2-)weighted MR imaging and therapy.
机译：目前，对成像和治疗功能的开发多功能治疗平台有很大的兴趣。在此，我们报告了一种容易性的方法来开发聚合物接枝的超顺磁性氧化铁纳米颗粒（胶片）作为用于成像和药物递送的有希望的系统。侧基的活化酯基团组成的无规共聚物，即，五氟苯基丙烯酸酯（PFPA）和聚乙二醇单甲醚甲基丙烯酸酯（PEGMA），合成和SPION接枝使用点击反应表面。使用FT-IR，XRD，XPS，TGA和TEM表征所得的多官能栓塞，证明它们在其表面上存在聚合物。通过细胞活力测定证实，形成的聚合性散热栓是水分散的，稳定的，并且是生物相容的。放松率测量表明，它们具有134.40mm（-1）S-1的T-2 *放松率（R（2）*），其高于商业FDA批准的MRI造影剂Ferumoxytol（85毫米（ -1）S-1）。此外，将多柔比星（DOX）加载到改性酱的聚合物壳上，并响应于酸性条件（pH 5.4）而表现出快速的药物释放。这些结果清楚地表明制备的改性栓塞具有很大的潜力，可以作为T（2-）加权MR成像和治疗的多官能纳米系统。

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  • 来源
    《RSC Advances》 |2016年第87期|共10页
  • 作者

    Asadi H.; Khoee S.; Deckers R.;

  • 作者单位

    Univ Tehran Polymer Lab Dept Chem Sch Sci POB 14155-6455 Tehran Iran;

    Univ Tehran Polymer Lab Dept Chem Sch Sci POB 14155-6455 Tehran Iran;

    Univ Med Ctr Utrecht Image Sci Inst Utrecht Netherlands;

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  • 正文语种 eng
  • 中图分类 化学;
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