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Maltitol-based biodegradable polyesters with tailored degradation and controlled release for bone regeneration

机译：基于麦芽醇的可生物降解聚酯，具有量身定制的降解和控制释放，用于骨再生

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摘要

Despite extensive research performed in the area of drug delivery and tissue engineering, the search for a perfect biomaterial remains an ongoing process. In an effort to find this material, novel maltitol-based polyesters using three different dicarboxylic acids (DCAs; adipic acid, dodecanedioic acid and suberic acid) were synthesized and their properties were investigated. The chemical structure of the polymers was confirmed using Fourier transform infrared and proton nuclear magnetic resonance spectroscopies. Thermal characterization revealed that the polymers were amorphous and that the glass transition temperature decreased with an increase in the chain length and molar ratio of maltitol : DCAs. Mechanical studies showed that the moduli of these polymers were comparable to those of the components of the skeletal system. Contact angle goniometry confirmed that the hydrophobicity of the polymers increased with increase in chain length and the molar ratio of maltitol : DCAs. The polymer degradation followed first order kinetics whereas dye release from these polymers followed zero order kinetics. Both the degradation and dye release studies demonstrated that the degradation and release decreased with increase in chain length and molar ratio of maltitol : DCA. The degradation and dye release can be modulated based on the chain length and the molar ratio of acids. Preliminary cytocompatibility studies showed that these polymers were cytocompatible. Mineralization studies revealed that these polymers showed increased mineralization when compared to results obtained with controls. Thus, this family of polyesters can serve as effective biomaterials for bone tissue engineering with tunable degradation and controlled release properties.
机译：尽管在药物递送和组织工程领域进行了广泛的研究，但搜索完美的生物材料仍然是持续的过程。为了找到这种材料，合成了使用三种不同二羧酸（DCAs;己二酸，十二烷基甲酸和脱柠檬）的新型麦芽糖基聚酯，并研究了它们的性质。使用傅里叶变换红外和质子核磁共振光谱来确认聚合物的化学结构。热表征显示，聚合物是无定形的，并且玻璃化转变温度随着麦芽糖醇的链长和摩尔比的增加而降低：DCAs。机械研究表明，这些聚合物的模态与骨骼系统的组分相当。接触角焦点证实，聚合物的疏水性随着链条长度和麦芽糖醇：DCA的摩尔比而增加。聚合物降解遵循第一阶动力学，而来自这些聚合物的染料释放，然后释放出零阶动力学。降解和染料释放研究表明，麦芽糖醇链长度和摩尔比的降解和释放降低：DCA。可以基于酸的链长和摩尔比来调节降解和染料释放。初步细胞组合性研究表明，这些聚合物是细胞偶联的。矿化研究表明，与用对照获得的结果相比，这些聚合物显示出矿化增加。因此，这种聚酯家族可以用作可调谐降解和控释性能的骨组织工程的有效生物材料。

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  • 来源
    《RSC Advances》 |2016年第46期|共13页
  • 作者

    Natarajan Janeni; Madras Giridhar; Chatterjee Kaushik;

  • 作者单位

    Indian Inst Sci Ctr Nano Sci &

    Engn Bangalore 560012 Karnataka India;

    Indian Inst Sci Dept Chem Engn Bangalore 560012 Karnataka India;

    Indian Inst Sci Dept Mat Engn Bangalore 560012 Karnataka India;

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  • 正文语种 eng
  • 中图分类 化学;
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