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A highly stable and biocompatible optical bioimaging nanoprobe based on carbon nanospheres

机译:基于碳纳米球的高稳态和生物相容性光学生物分析纳米剖视图

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摘要

In this report, a facile one-step synthesis strategy has been developed for producing fluorescent carbon nanospheres (CNs) using lactobionic acid (LBA) as a precursor. The resulting CNs are highly stable in aqueous solution with an average size of 120 nm. The obtained CNs contained large amounts of -OH and -COOH on their surfaces which will facilitate further functionalization for more additional usage. In addition, carbon nanospheres possess an intrinsic fluorescence property so they can be used for fluorescence imaging. Our CNs exhibited remarkable photoluminescence properties and low cytotoxicity which can be used to label living cells with high efficiency, suggesting potential applications in biolabeling and bioimaging. In brief, we developed novel fluorescent carbon nanospheres with high stability, biocompatibility and labeling efficiency for cell imaging, as well as abundant active groups on their surface for further modifications.
机译:在本报告中,已经开发了一种用于使用氯苯乙酸(LBA)作为前体的荧光碳纳米球(CNS)制备了容易的一步合成策略。 所得CNS在水溶液中的平均尺寸为120nm的水溶液中高度稳定。 所得CNS含有大量的-OH和-COOH,其表面将促进进一步的官能化以获得更多额外的用途。 此外,碳纳米球具有内在荧光性能,因此它们可用于荧光成像。 我们的CNS表现出显着的光致发光性质和低细胞毒性,可用于标记高效率的活细胞,表明生物标记和生物成像中的潜在应用。 简而言之,我们开发了具有高稳定性,生物相容性和细胞成像的稳定性,生物相容性和标记效率的新型荧光碳纳米球,以及其表面上的丰富活性组以进一步修饰。

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  • 来源
    《RSC Advances》 |2016年第44期|共6页
  • 作者单位

    Fujian Med Univ Liver Ctr Fujian Prov Fuzhou Peoples R China;

    Fujian Med Univ Liver Ctr Fujian Prov Fuzhou Peoples R China;

    Fujian Med Univ Liver Ctr Fujian Prov Fuzhou Peoples R China;

    Fujian Med Univ Liver Ctr Fujian Prov Fuzhou Peoples R China;

    Fujian Med Univ Liver Ctr Fujian Prov Fuzhou Peoples R China;

    Fujian Normal Univ Fujian Prov Key Lab Photon Technol Minist Educ Key Lab Optoelect Sci &

    Technol Med Fuzhou Peoples R China;

    Fujian Med Univ Liver Ctr Fujian Prov Fuzhou Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

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