Biomimetic design: a programmed tetradecapeptide folds and auto-dimerizes as a stereochemically articulated receptor protein

Ghosh Punam; Pednekar Deepa; Durani Susheel

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Biomimetic design: a programmed tetradecapeptide folds and auto-dimerizes as a stereochemically articulated receptor protein

机译：仿生设计：编程的四肽折叠并作为立体化学铰接受体蛋白自动分化

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In order to mimic biogeny, protein-quaternary structure may be evolved to the desired structure specificity-as a fold, assembly, and sequence-in a hierarchy of independent design steps. In demonstration of the algorithm, octapeptides were accomplished to obtain the desired structural specificity as folds, assemblies, and sequences over a hierarchy of design steps; the approach was shown to extend the structure by allowing amino acid stereochemistry to be applied as a design variable. Moreover, it was proven to simplify design by allowing the programming to involve a hierarchy of independent steps. Illustrating the abovementioned approach of biomimetic design with involvement of amino acid stereochemistry as the design variable, we now report an example of functional design, in which a fourteen-residue sequence was accomplished to the desired binding specificity as a receptor protein, first in the fold stereochemically, then in the assembly spatially, and finally in the sequence chemically.

机译：为了模仿生物代理，可以将蛋白质 - 季结构的结构演变为所需的结构特异性 - 作为折叠，组装和序列 - 在独立设计步骤的层次结构中。在算法的示范中，完成八肽以在设计步骤的层级上获得所需的结构特异性作为折叠，组件和序列;通过允许氨基酸立体化学作为设计变量施加氨基酸立体化学来显示该方法。此外，通过允许编程涉及独立步骤的层次，它被证明是简化设计。说明亚氨基酸立体化学促进作为设计变量的上述仿生设计方法，我们现在报告了功能性设计的一个例子，其中将十四个残基序列作为受体蛋白质完成所需的结合特异性，首先在折叠中完成立体化学上，然后在空间上在组装中，最后在化学上序列。

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《RSC Advances》 |2016年第8期|共7页
作者
Ghosh Punam; Pednekar Deepa; Durani Susheel;
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Indian Inst Technol Dept Chem Bombay 400076 Maharashtra India;

Indian Inst Technol Dept Chem Bombay 400076 Maharashtra India;

Indian Inst Technol Dept Chem Bombay 400076 Maharashtra India;

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正文语种 eng
中图分类化学;
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1. Biomimetic design: a programmed tetradecapeptide folds and auto-dimerizes as a stereochemically articulated receptor protein [J] . Ghosh Punam, Pednekar Deepa, Durani Susheel RSC Advances . 2016,第8期

机译：仿生设计：编程的四肽折叠并作为立体化学铰接受体蛋白自动分化
2. Large-scale linear programming techniques for the design of protein folding potentials [J] . Wagner M, Meller J, Elber R Mathematical Programming . 2004,第2期

机译：用于蛋白质折叠电位设计的大规模线性编程技术
3. Large-scale linear programming techniques for the design of protein folding potentials [J] . Michael Wagner, Jarosław Meller, Ron Elber Mathematical Programming . 2004,第2期

机译：用于蛋白质折叠电位设计的大规模线性编程技术
4. Hierarchic Folding and Assembly of CN-Symmetric Homo- Ollgomers: Demonstration of Chemical and Stereochemical Variables of Polypeptide Structure as the Design Alphabet [C] . Punam Ghosh, Susheel Durani American Peptide Symposium . 2011

机译：CN对称同源聚合物的层次折叠和组装：作为设计字母表的多肽结构的化学和立体化学变量的演示
5. I. Protein design: Reengineering cellular retinoic acid binding protein II into a retinal binding protein. II. Pseudo-caged compounds as chromophoric hosts for the absolute stereochemical determination of chiral compounds. [D] . Vasileiou, Chrysoula. 2005

机译：I.蛋白质设计：将细胞视黄酸结合蛋白II改造成视网膜结合蛋白。二。伪笼状化合物作为发色宿主，用于绝对立体化学测定手性化合物。
6. Design of RNAs: comparing programs for inverse RNA folding [O] . Alexander Churkin, Matan Drory Retwitzer, Vladimir Reinharz, -1

机译：RNA设计：比较反向RNA折叠程序
7. Large-scale linear programming techniques for the design of protein folding potentials [O] . Michael Wagner, Jarosław Meller, Ron Elber 2004

机译：用于蛋白质折叠电位设计的大规模线性编程技术

Biomimetic design: a programmed tetradecapeptide folds and auto-dimerizes as a stereochemically articulated receptor protein

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