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Water soluble stimuli-responsive star copolymers with multiple encapsulation and release properties

机译：具有多种封装和释放性能的水溶性刺激响应恒星共聚物

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摘要

A series of three arm star shaped (random/block) and linear water soluble copolymers are synthesised by atom transfer radical polymerization (ATRP) using di(ethylene glycol) methyl ether methacrylate (DEGMA) and 2-(dimethylamino) ethyl methacrylate (DMAEMA). The structure and composition of the block and random copolymers are characterized by H-1 NMR spectra and gel permeation chromatography (GPC). The self-assembly of these copolymers, investigated by dynamic light scattering (DLS), exhibits that below the lower critical solution temperature (LCST) of pDEGMA all the copolymers are soluble in water and possess lower particle size but above its LCST particle size increases particularly in a basic medium. On addition of 8-anilino-1-naphthalenesulfonic acid (ANS) the particle size increases by similar to 10 times below the LCST. Both the DLS and fluorescence studies using a hydrophobic fluorescent dye, exhibit temperature triggered encapsulation and pH triggered release. All the copolymers exhibit highly reversible multiple aggregation at different temperature and pH conditions and require increased temperature for the aggregation with decrease in pH of the medium. The random star copolymer [3-arm-p(DEGMA(40)-co-DMAEMA(18))] exhibits aggregate formation under physiological conditions (37 degrees C and pH 7.5) and with decreasing the pH to 6.5 the aggregates dissociate. The MTT assay and cell morphology indicate that the three arm star and linear random copolymers have lower cytotoxicity against normal CHO-K1 cells having lower positive zeta potential values.
机译：通过原子传递自由基聚合（ATRP）使用二（乙二醇）甲基醚甲基丙烯酸甲酯（DEGMA）和2-（二甲基氨基）乙基丙烯酸乙酯（DMAEMA）来合成一系列三个臂星形（随机/嵌段）和线性水溶性共聚物。（DMAEMA） 。嵌段和无规共聚物的结构和组合物的特征在于H-1 NMR光谱和凝胶渗透色谱法（GPC）。通过动态光散射（DLS）研究的这些共聚物的自组装表现出低于PDEGMA的低临界溶液温度（LCST），所有共聚物都可溶于水并具有较低的粒度，但在其LCST粒度之上特别增加在基本培养基中。添加了8-苯基-1-萘磺酸（ANS），粒度随着LCST的10倍而增加。使用疏水荧光染料的DLS和荧光研究，表现出温度触发的包封和pH触发释放。所有共聚物在不同的温度和pH条件下表现出高度可逆的多聚集体，并且需要在培养基的pH值下降的聚集温度增加。随机星共聚物[3臂-P（Degma（40）-co-dmaema（18））]在生理条件下表现出聚集体形成（37℃和pH7.5），并将pH降至6.5，聚集体解离。 MTT测定和细胞形态表明，三个臂星和线性随机共聚物对具有较低阳性ζ电位值的正常CHO-K1细胞具有较低的细胞毒性。

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  • 来源
    《RSC Advances》 |2016年第11期|共13页
  • 作者

    Das Sandip; Chatterjee Dhruba P.; Ghosh Radhakanta; Das Pradip; Nandi Arun K.;

  • 作者单位

    Indian Assoc Cultivat Sci Polymer Sci Unit Kolkata 700032 India;

    Indian Assoc Cultivat Sci Polymer Sci Unit Kolkata 700032 India;

    Indian Assoc Cultivat Sci Polymer Sci Unit Kolkata 700032 India;

    Indian Assoc Cultivat Sci Polymer Sci Unit Kolkata 700032 India;

    Indian Assoc Cultivat Sci Polymer Sci Unit Kolkata 700032 India;

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  • 正文语种 eng
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