Au(I) N-heterocyclic carbenes from bisimidazolium amphiphiles: synthesis, cytotoxicity and incorporation onto gold nanoparticles

Rodrigues M.; Russo L.; Aguilo E.; Rodriguez L.; Ott I.; Perez-Garcia L.

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Au(I) N-heterocyclic carbenes from bisimidazolium amphiphiles: synthesis, cytotoxicity and incorporation onto gold nanoparticles

机译：来自Bisimidazolium两亲物的Au（i）N-杂环碳：合成，细胞毒性和掺入金纳米粒子上

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A gold(I) N-heterocyclic carbene 4 from a bis-imidazolium- amphiphile was synthesized and characterized. The cytotoxicity against HT-29 colon carcinoma and MDA-MB-231 breast adenocarcinoma cells was assessed for the NHC complex 4, the imidazolium salt precursor 2, and its methyl analogue 3, indicating that compounds 2-4 are promising cytotoxic agents. Furthermore, the ability of these compounds to be associated with gold nanoparticles was also explored, in order to develop an anticancer drug delivery system. The free ligands displayed more activity when compared with the ligands immobilized on the gold nanoparticles. The synthesized gold particles incorporating the bis-imidazolium salts either 2 or 3 showed monodisperse spherical shape with sizes of approximately 5 nm.

机译：合成并表征来自双咪唑鎓 - 两亲咪唑的金（I）N-杂环切菜4。对HT-29结肠癌和MDA-MB-231乳腺腺癌细胞的细胞毒性评估NHC络合物4，咪唑鎓盐前体2及其甲基类似物3，表明化合物2-4是有前途的细胞毒性剂。此外，还探讨了这些化合物与金纳米颗粒相关的能力，以开发抗癌药物递送系统。与固定在金纳米颗粒上的配体相比，自由配体显示更多的活性。合成的金颗粒包含双 - 咪唑鎓盐2或3的单分散球形，尺寸约为5nm。

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来源
《RSC Advances》 |2016年第3期|共8页
作者
Rodrigues M.; Russo L.; Aguilo E.; Rodriguez L.; Ott I.; Perez-Garcia L.;
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作者单位

Univ Barcelona Dept Farmacol &

Quim Terapeut E-08028 Barcelona Spain;

Univ Barcelona Dept Farmacol &

Quim Terapeut E-08028 Barcelona Spain;

Univ Barcelona Dept Quim Inorgan E-08028 Barcelona Spain;

Univ Barcelona Dept Quim Inorgan E-08028 Barcelona Spain;

Tech Univ Carolo Wilhelmina Braunschweig Inst Med &

Pharmaceut Chem D-38106 Braunschweig Germany;

Univ Barcelona Dept Farmacol &

Quim Terapeut E-08028 Barcelona Spain;

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正文语种 eng
中图分类化学;
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机译：来自Bisimidazolium两亲物的Au（i）N-杂环碳：合成，细胞毒性和掺入金纳米粒子上
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Au(I) N-heterocyclic carbenes from bisimidazolium amphiphiles: synthesis, cytotoxicity and incorporation onto gold nanoparticles

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