Artificial extracellular matrix delivers TGFb1 regulating myofibroblast differentiation

Cheng Weilu; Xu Ruodan; Li Dalong; Bortolini Christian; He Jinmei; Dong Mingdong; Besenbacher Flemming; Huang Yudong; Chen Menglin

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Artificial extracellular matrix delivers TGFb1 regulating myofibroblast differentiation

机译：人造细胞外基质提供TGFB1调节肌纤维细胞分化

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During wound healing, the contractile activity of myofibroblasts differentiated from fibroblasts in active transforming growth factor beta 1 (TGF beta 1) conditions has vital functions. In wound dressing biomaterials, it is crucial to mimic the extracellular matrix to deliver the right amount of TGFb1 in a spatiotemporally controlled manner. We report here, for the first time, a zero-order, sustained TGFb1 release from electrospun biomimetic nanofibers realizing optimal cell viability and myofibroblast differentiation capacity, confirmed by cell metabolic activity CCK assay, gene expression level through real-time PCR and protein expression level through immunochemical staining.

机译：在伤口愈合期间，从活性转化生长因子β1（TGFβ1）条件下的成纤维细胞分化的肌纤维细胞的收缩活性具有重要的功能。在伤口敷料生物材料中，模拟细胞外基质至关重要，以发短的方式递送适量的TGFB1。我们在此报告，首次进行零阶持续的TGFB1从Electrom淘性的仿生纳米纤维释放，实现最佳的细胞活力和肌纤维细胞分化能力，通过细胞代谢活性CCK测定，通过实时PCR和蛋白表达水平来证实基因表达水平通过免疫化学染色。

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来源
《RSC Advances》 |2016年第26期|共7页
作者
Cheng Weilu; Xu Ruodan; Li Dalong; Bortolini Christian; He Jinmei; Dong Mingdong; Besenbacher Flemming; Huang Yudong; Chen Menglin;
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作者单位

Harbin Inst Technol Sch Chem Engn &

Technol State Key Lab Urban Water Resource &

Environm Harbin 150001 Peoples R China;

Aarhus Univ Interdisciplinaly Nanosci Ctr iNANO DK-8000 Aarhus C Denmark;

Harbin Inst Technol Sch Chem Engn &

Technol State Key Lab Urban Water Resource &

Environm Harbin 150001 Peoples R China;

Aarhus Univ Interdisciplinaly Nanosci Ctr iNANO DK-8000 Aarhus C Denmark;

Harbin Inst Technol Sch Chem Engn &

Technol State Key Lab Urban Water Resource &

Environm Harbin 150001 Peoples R China;

Aarhus Univ Interdisciplinaly Nanosci Ctr iNANO DK-8000 Aarhus C Denmark;

Aarhus Univ Interdisciplinaly Nanosci Ctr iNANO DK-8000 Aarhus C Denmark;

Harbin Inst Technol Sch Chem Engn &

Technol State Key Lab Urban Water Resource &

Environm Harbin 150001 Peoples R China;

Aarhus Univ Interdisciplinaly Nanosci Ctr iNANO DK-8000 Aarhus C Denmark;

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正文语种 eng
中图分类化学;
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1. Artificial extracellular matrix delivers TGFb1 regulating myofibroblast differentiation [J] . Cheng Weilu, Xu Ruodan, Li Dalong, RSC Advances . 2016,第26期

机译：人造细胞外基质提供TGFB1调节肌纤维细胞分化
2. Artificial extracellular matrix composed of collagen I and highly sulfated hyaluronan interferes with TGFβ(1) signaling and prevents TGFβ(1)-induced myofibroblast differentiation. [J] . Anja van der Smissen, Sergey Samsonov, Vera Hintze, Acta biomaterialia . 2013,第8期

机译：由胶原I和高硫酸化透明质酸组成的人造细胞外基质干扰TGFβ（1）信号传导并防止TGFβ（1） - 诱导肌纤维细胞分化。
3. Syndecan-4 signaling via NFAT regulates extracellular matrix production and cardiac myofibroblast differentiation in response to mechanical stress [J] . HerumK.M., LundeI.G., SkrbicB., Journal of Molecular and Cellular Cardiology . 2013,第1期

机译：通过NFAT产生的Syndecan-4信号调节细胞外基质的产生和对心肌成纤维细胞的分化，以应对机械压力
4. Syncytial Myoblast Fusion is Regulated by Muscle Extracellular Matrix and Integrin α7β1 Signaling [C] . Michael J. McClure, D. Joshua Cohen, MoonHae Sunwoo, Society for Biomaterials annual meeting and exposition . 2017

机译：合胞成肌细胞融合受肌肉细胞外基质和整联蛋白α7β1信号传导的调节。
5. The effects of tensile loading and extracellular environmental cues on fibroblastic differentiation and extracellular matrix production by mesenchymal stem cells [D] . Doroski, Derek M. 2011

机译：拉伸负荷和细胞外环境提示对间充质干细胞成纤维细胞分化和细胞外基质产生的影响
6. Extracellular Matrix Stiffness and Composition Regulate the Myofibroblast Differentiation of Vaginal Fibroblasts [O] . Alejandra M. Ruiz-Zapata, Andrea Heinz, Manon H. Kerkhof, 2020

机译：细胞外基质的刚度和成分调节阴道成纤维细胞的成纤维细胞分化
7. Extracellular Matrix Stiffness and Composition Regulate the Myofibroblast Differentiation of Vaginal Fibroblasts [O] . Alejandra M. Ruiz-Zapata, Andrea Heinz, Manon H. Kerkhof, 2020

机译：细胞外基质刚度和组成调节阴道成纤维细胞的肌纤维细胞分化

Artificial extracellular matrix delivers TGFb1 regulating myofibroblast differentiation

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