Delavatine A, a structurally unusual cyclopenta[de]isoquinoline alkaloid from Incarvillea delavayi

Zhang Zhongyin; Yang Fan; Fu Jian-Jun; Shen Yun-Heng; He Weiwei; Zhang Wei-Dong

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Delavatine A, a structurally unusual cyclopenta[de]isoquinoline alkaloid from Incarvillea delavayi

机译：deravatine a，来自incarvillea delavayi的结构性不寻常的cyclopenta [de]异喹啉生物碱

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Natural products have long been an important source for the discovery of biologically active compounds, in particular, drug leads. Delavatine A (1), a structurally unusual cyclopenta[de]isoquinoline alkaloid, was isolated from Incarvillea delavayi. Extensive spectroscopic analysis, in combination with biogenetic speculation, established the structure of 1. Delavatine A (1) exhibited considerable cytotoxicity against a number of cancer cell lines with IC50 values in the range of 4.28 to 6.61 mu g mL(-1).

机译：天然产品长期以来一直是发现生物活性化合物的重要来源，特别是药物引线。 Delavatine A（1）是一种结构不寻常的环戊基[DE]异喹啉生物碱，从incarvillea delavayi中分离出来。广泛的光谱分析与生物涂布组合，建立了1.DeraVatine A（1）的结构，其具有相当大的细胞毒性，其具有IC50值的癌细胞系数为4.28至6.61μg（-1）。

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来源
《RSC Advances》 |2016年第70期|共4页
作者
Zhang Zhongyin; Yang Fan; Fu Jian-Jun; Shen Yun-Heng; He Weiwei; Zhang Wei-Dong;
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Second Mil Med Univ Sch Pharm Dept Phytochem Shanghai 200433 Peoples R China;

East China Univ Sci &

Technol Sch Pharm 130 Meilong Rd Shanghai 200237 Peoples R China;

East China Univ Sci &

Technol Sch Pharm 130 Meilong Rd Shanghai 200237 Peoples R China;

Second Mil Med Univ Sch Pharm Dept Phytochem Shanghai 200433 Peoples R China;

East China Univ Sci &

Technol Sch Pharm 130 Meilong Rd Shanghai 200237 Peoples R China;

Second Mil Med Univ Sch Pharm Dept Phytochem Shanghai 200433 Peoples R China;

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正文语种 eng
中图分类化学;
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1. A new iridoid from Incarvillea delavayi [J] . 中国化学快报（英文版） . 2007,第012期
2. Delavatine A, a structurally unusual cyclopenta[de]isoquinoline alkaloid from Incarvillea delavayi [J] . Zhang Zhongyin, Yang Fan, Fu Jian-Jun, RSC Advances . 2016,第70期

机译：deravatine a，来自incarvillea delavayi的结构性不寻常的cyclopenta [de]异喹啉生物碱
3. Two Novel Actinidine-Type Monoterpene Alkaloids from Incarvillea delavayi [J] . Motoyuki Nakamura, Katsumi Kido, Junei Kinjo, Chemical and Pharmaceutical Bulletin . 2000,第11期

机译：来自Incarvillea delavayi的两种新型Act替啶型单萜生物碱
4. Isoquinoline alkaloids from Thalictrum delavayi. [J] . Li M, Chen X, Tang QM, Planta medica: Natural products and medicinal plant research . 2001,第2期

机译：拟南芥中的异喹啉生物碱。
5. Novel P450s in isoquinoline alkaloid biosynthesis [C] . Sato F., Ikezawa N., Iwasa K., International Conference on Cytochrome P450 . 2009

机译：异喹啉生物碱生物合成中的新型P450s
6. Development of the asymmetric intermolecular aza-[3+3] annulation and the intramolecular aza-[3+3] annulation with enones, applications to idolizidine and isoquinoline alkaloid syntheses [D] . Buchanan, Grant Stephen 2011

机译：烯酮不对称分子间氮杂[3 + 3]环空和分子内氮杂[3 + 3]环空的发展及其在异吲哚和异喹啉生物碱合成中的应用
7. Analysis of alkaloids (indole alkaloids isoquinoline alkaloids tropane alkaloids) [O] . Prasanta Dey, Amit Kundu, Anoop Kumar, -1

机译：生物碱的分析（吲哚生物碱异喹啉生物碱酞甲酸盐生物碱）
8. Two Novel Actinidine-Type Monoterpene Alkaloids from Incarvillea delavayi. [O] . Motoyuki NAKAMURA, Katsumi KIDO, Junei KINJO, 2000

机译：来自incarvillea delavayi的两种新型猕猴桃型单萜类生物碱。
9. Synthesis and Biological Activity of Cyclopenta Epoxides of PAH (Polycyclic Aromatic Hydrocarbons) Containing Peripherally Fused Cyclopenta Rings [R] . Bartczak, A. W. , Sangaiah, R. , Ball, L. M. , 1985

机译：含有外围稠合环戊二烯的paH（多环芳烃）环戊二烯环氧化物的合成及生物活性

Delavatine A, a structurally unusual cyclopenta[de]isoquinoline alkaloid from Incarvillea delavayi

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