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Multifunctional polymer nanoparticles: ultra bright near-infrared fluorescence and strong magnetization and their biological applications

机译：多官能聚合物纳米粒子：超明显近红外荧光和强磁化及其生物应用

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摘要

Multifunctional polymer nanoparticles with great promise for biomedical applications have attracted many attentions. Using an aggregation-enhanced emission (AEE) molecule DPPBPA and magnetic Fe3O4 as the core, and biocompatible polymer Pluronic F-127 as the encapsulation matrix, multifunctional polymer NPs Fe3O4/DPPBPA@F-127 were fabricated by self-assembly procedures. These NPs have bright near-infrared fluorescence lex at 654 nm with a high fluorescence quantum yield of 18.3%, and strong magnetism, and superparamagnetism. With good monodispersity and biocompatibility, the NPs not only can show effective MRI ability, but also can stain in cytoplasm with a strong near-infrared fluorescent signal, as well as little toxicity to living cells, which show a very good prospect in the field of biological applications.
机译：具有良好对生物医学应用的多功能聚合物纳米粒子引起了许多关注。 使用聚集增强的发射（AEE）分子DPPBPA和磁Fe3O4作为核心，并且生物相容性聚合物Pluronic F-127作为封装基质，通过自组装方法制造多官能聚合物NPS Fe3O4 / DPPBPA @ F-127。 这些NPS在654nm处具有明亮的近红外荧光LEX，荧光量子产率为18.3％，磁力强，磁性强度和超级磁性。 具有良好的单一性和生物相容性，NPS不仅可以显示出有效的MRI能力，而且可以在细胞质中染色，具有强烈的近红外荧光信号，以及对活细胞的毒性很小，这在领域表示了一个非常好的前景 生物学应用。

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  • 来源
    《RSC Advances》 |2016年第70期|共8页
  • 作者

    Yan Lulin; Zhang Yan; Ji Guang; Ma Lian; Chen Jinlong; Xu Bin; Tian Wenjing;

  • 作者单位

    Jilin Univ State Key Lab Supramol Struct &

    Mat Changchun 130012 Peoples R China;

    Jilin Univ State Key Lab Supramol Struct &

    Mat Changchun 130012 Peoples R China;

    Jilin Univ State Key Lab Supramol Struct &

    Mat Changchun 130012 Peoples R China;

    Jilin Univ State Key Lab Supramol Struct &

    Mat Changchun 130012 Peoples R China;

    Jilin Univ State Key Lab Supramol Struct &

    Mat Changchun 130012 Peoples R China;

    Jilin Univ State Key Lab Supramol Struct &

    Mat Changchun 130012 Peoples R China;

    Jilin Univ State Key Lab Supramol Struct &

    Mat Changchun 130012 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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