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首页> 外文期刊>RSC Advances >Photosynthesized silver-polyaminocyclodextrin nanocomposites as promising antibacterial agents with improved activity
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Photosynthesized silver-polyaminocyclodextrin nanocomposites as promising antibacterial agents with improved activity

机译：光合银 - 多氨基环素峰纳米复合材料作为具有改善活性的有前途的抗菌剂

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摘要

Ag nanocomposites were prepared by photoreduction of ammoniacal silver acetate in the presence of poly-{6-[3-(2-(3-aminopropylamino)ethylamino)propylamino]}-(6-deoxy)-beta-CD (amCD). The obtained systems were characterized by means of various complementary techniques (UV-vis, FT-IR, TEM, SAED). In particular, FT-IR spectroscopy evidenced a partial oxidative degradation of the polyamine branches of the capping auxiliary, due to the fact that these groups function as a sacrificial reducing agent in the photoinduced formation of the Ag metal core. TEM and SAED micrographs showed that the Ag cores possess a relatively low polydispersity and a significantly crystalline character. The Ag-amCD systems were assayed for antibacterial activity, using Escherichia coli and Kocuria rhizophila as Gram-negative and Gram-positive tester strains respectively. In addition, the systems function as supramolecular drug carriers, able to bind the beta-lactam antibiotic ampicillin, as demonstrated by polarimetric measurements. Antimicrobial assays revealed MIC90 values against E. coli and K. rhizophila as large as a 5 and 1 mu g mL(-1) respectively. Moreover, the interaction of the Ag-amCD with ampicillin resulted in a synergistic improvement of the antibacterial activity. This study provides insights on the attractive possibility to use a photochemical methodology to produce bioactive supramolecular systems to be employed as powerful and tunable antimicrobial agents.
机译：通过在聚 - {6-（2-（2-（3-氨基丙基）乙基氨基）丙基氨基存在下的酰胺乙酸氨酸乙酸盐中来制备Ag纳米复合材料。（6-脱氧）-Beta-CD（AMCD）。通过各种互补技术（UV-Vis，FT-IR，TEM，SAED）表征所获得的系统。特别地，FT-IR光谱证明了封端助剂的多胺分支的部分氧化降解，因为这些基团在Ag金属芯的光致形成的牺牲还原剂中起作用。 TEM和SAED显微照片显示AG核心具有相对低的多分散性和显着结晶的特征。测定Ag-AMCD系统以分别使用大肠杆菌和科松毒液中的抗菌活性作为革兰阴性和革兰氏阳性测试菌株。此外，系统用作超分子药物载体，能够结合β-内酰胺抗生素氨苄青霉素，如极化测量所证明。抗微生物测定分别揭示了MIC90对大肠杆菌和K.Hthizophila分别为5和1μgmm（-1）的rhizophila。此外，Ag-AMCD与氨苄青霉素的相互作用导致抗菌活性的协同改善。本研究提供了利用光化学方法生产生物活性超分子系统的有吸引力的可能性的见解，该系统用作强大而可调抗微生物剂的生物活性超分子系统。

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  • 来源
    《RSC Advances》 |2016年第46期|共10页
  • 作者

    Russo Marco; Meli Alessandro; Sutera Alberto; Gallo Giuseppe; Martino Delia Chillura; Lo Meo Paolo; Noto Renato;

  • 作者单位

    Univ Palermo Dipartimento Sci &

    Tecnol Biol Chem &

    Farmaceut Vle Sci Parco Orleans Pad 17 I-90128 Palermo Italy;

    Univ Palermo Dipartimento Sci &

    Tecnol Biol Chem &

    Farmaceut Vle Sci Parco Orleans Pad 17 I-90128 Palermo Italy;

    Univ Palermo Dipartimento Sci &

    Tecnol Biol Chem &

    Farmaceut Vle Sci Parco Orleans Pad 17 I-90128 Palermo Italy;

    Univ Palermo Dipartimento Sci &

    Tecnol Biol Chem &

    Farmaceut Vle Sci Parco Orleans Pad 17 I-90128 Palermo Italy;

    Univ Palermo Dipartimento Sci &

    Tecnol Biol Chem &

    Farmaceut Vle Sci Parco Orleans Pad 17 I-90128 Palermo Italy;

    Univ Palermo Dipartimento Sci &

    Tecnol Biol Chem &

    Farmaceut Vle Sci Parco Orleans Pad 17 I-90128 Palermo Italy;

    Univ Palermo Dipartimento Sci &

    Tecnol Biol Chem &

    Farmaceut Vle Sci Parco Orleans Pad 17 I-90128 Palermo Italy;

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