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首页> 外文期刊>RSC Advances >A high selective and sensitive method for the detection of six psychotropic drugs in human urine by high performance liquid chromatography combined with resonance Rayleigh scattering spectra
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A high selective and sensitive method for the detection of six psychotropic drugs in human urine by high performance liquid chromatography combined with resonance Rayleigh scattering spectra

机译：高效液相色谱与共振瑞利散射光谱相结合检测人类尿6六种精神药物的高选择性和敏感方法

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摘要

A highly selective and sensitive method of high performance liquid chromatography combined with resonance Rayleigh scattering spectra was developed for the detection of six psychotropic drugs, including Doxepin, Promethazine, Imipramine, Amitriptyline, Chlorpromazine and Clomipramine. This method was based on the weak intensity of the RRS of six drugs and its significant enhancement after combined with Erythrosine (Ery) in a pH 4.0-4.7 BR buffer solution. The linear range was between 0.05 and 20 mg mL (1) with correlation coefficients (r) all above 0.9916. The limits of detection (S/N = 3) were in the range of 0.42 and 21.05 ng mL(-1). Because the RRS detection wavelength was special (the excitation wavelength was equal to the emission wavelength, lambda(ex) = lambda(em) = 295 nm) and some other substances in human urine do not form ion-association complex with the Ery, no interference from the matrix was observed. The proposed method was successfully applied to real human urine samples analysis.
机译：高效液相色谱法与共振瑞利散射光谱相结合的高度选择性和敏感方法，用于检测六种精神药物，包括Doxepin，丙嗪，含染色药物，氨基丙嘧啶，氯丙嗪和划分。该方法基于六种药物RRS的弱强度及其在pH 4.0-4.7 BR缓冲溶液中结合赤藓胺（胺）后的显着增强。线性范围在0.05-20mg mL（1）之间，相关系数（R）全部高于0.9916。检测限范率（S / N = 3）的范围为0.42和21.05 ng ml（-1）。因为RRS检测波长特殊（激发波长等于发光波长，因此Lambda（Ex）=λ（EM）= 295nm）和人类尿液中的一些其他物质不会与红细胞形成离子关联复合物，没有观察到矩阵的干扰。该方法已成功应用于真正的人类尿液样本分析。

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  • 来源
    《RSC Advances》 |2015年第89期|共8页
  • 作者

    Zang Xu; Peng Jingdong; Zhou Mingqiong; Peng Huanjun;

  • 作者单位

    Southwest Univ Sch Chem &

    Chem Engn Chongqing 400715 Peoples R China;

    Southwest Univ Sch Chem &

    Chem Engn Chongqing 400715 Peoples R China;

    Southwest Univ Sch Chem &

    Chem Engn Chongqing 400715 Peoples R China;

    Southwest Univ Sch Chem &

    Chem Engn Chongqing 400715 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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