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首页> 外文期刊>RSC Advances >Nanotopological-tailored calcium phosphate cements for the odontogenic stimulation of human dental pulp stem cells through integrin signaling
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Nanotopological-tailored calcium phosphate cements for the odontogenic stimulation of human dental pulp stem cells through integrin signaling

机译：通过整合素信号传导，纳米缺乏定制的磷酸钙水泥用于人体牙髓干细胞的牙突刺激

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摘要

Calcium phosphate cements (CPCs) are a unique class of inorganic injectables attractive for the repair and regeneration of hard tissues. Tailoring the crystallite properties of CPC, particularly to represent nanotopological features, is favorable for stimulating biological reactions. Nanotopological tailoring has recently been achieved on CPCs by simply modulating the sizes of the initial particles. Herein, we aim to investigate the effects of nanotopological-tailored CPCs on the odontogenic differentiation of stem cells derived from human dental pulp (HDPSCs) as well as on their implicated signal pathways. The initial adhesion of the cells was substantially higher on nano-CPCs than on micro-CPCs. A series of indications of odontogenesis, including alkaline phosphatase activity and gene expressions (dentin matrix protein-1, dentin sialophosphoprotein, osteocalcin, ostepontin, and bone sialoprotein) were significantly stimulated on the nano-CPC in comparison to the micro-CPC. Furthermore, the integrin downstream pathways of the cells, including FAK, paxillin, Akt, MAPK, and NF-kappa B, were highly activated on the nano-CPC with respect to those on the micro-CPCs. Collectively, the nanotopological CPCs significantly enhance the odontogenic differentiation of HDPSCs when compared to conventional micro-CPCs through the integrin-associated signaling pathways, which implies that the nanotopological CPCs may be more potent in the repair and regeneration of dentin-pulp complex tissues.
机译：磷酸钙水泥（CPC）是一种独特的无机注射剂，用于修复和再生硬组织。剪裁CPC的微晶特性，特别是表示纳米音阶功能，有利于刺激生物反应。通过简单地调节初始颗粒的尺寸，最近在CPC上实现了纳米音阶剪裁。在此，我们的目的是探讨纳米腔内定制CPC对衍生自人牙髓（HDPSCS）的干细胞的异肠病分化的影响以及其牵伸信号途径。纳米CPC的初始粘附基本上高于微量CPC。与微量CPC相比，在纳米CPC上显着刺激了含碱性磷酸酶活性和基因表达（牙本质基质蛋白-1，牙本质磷酰蛋白，Osteocalcin，Osteocalcin，Osteocalcin，Osteocalcin和骨蛋白酶，并且与微量CPC显着刺激纳米CPC。此外，在纳米CPC上相对于微量CPC的细胞，包括FAK，Paxillin，AKT，MAPK和NF-Kappa B的细胞的整数下游途径高度激活。总的来说，与常规微量CPC通过整合素相关的信号通路相比，纳米腔学CPC显着提高HDPSC的异常分化，这意味着在牙本质 - 纸浆复合组织的修复和再生中可能更有效地具有更有效的。

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  • 来源
    《RSC Advances》 |2015年第78期|共9页
  • 作者

    Lee So-Youn; Yun Hyung-Mun; Perez Roman A.; Gallinetti Sara; Ginebra Maria-Pau; Choi Seong-Jun; Kim Eun-Cheol; Kim Hae-Won;

  • 作者单位

    Kyung Hee Univ Sch Dent Dept Oral &

    Maxillofacial Pathol Seoul 130701 South Korea;

    Kyung Hee Univ Sch Dent Dept Oral &

    Maxillofacial Pathol Seoul 130701 South Korea;

    Dankook Univ Inst Tissue Regenerat Engn ITREN Cheonan 330714 South Korea;

    Tech Univ Catalonia UPC Dept Mat Sci &

    Met Biomat Biomech &

    Tissue Engn Grp E-08028 Barcelona Spain;

    Tech Univ Catalonia UPC Dept Mat Sci &

    Met Biomat Biomech &

    Tissue Engn Grp E-08028 Barcelona Spain;

    Dankook Univ Inst Tissue Regenerat Engn ITREN Cheonan 330714 South Korea;

    Kyung Hee Univ Sch Dent Dept Oral &

    Maxillofacial Pathol Seoul 130701 South Korea;

    Dankook Univ Inst Tissue Regenerat Engn ITREN Cheonan 330714 South Korea;

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