• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >Influence of water vapour with non-thermal plasma jet on the apoptosis of SK-BR-3 breast cancer cells
【24h】

Influence of water vapour with non-thermal plasma jet on the apoptosis of SK-BR-3 breast cancer cells

机译：非热等离子体喷射水蒸气对SK-BR-3乳腺癌细胞凋亡的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A new approach for cancer treatment is based on the congenital overproduction of hydroxyl radicals (OH) and hydrogen peroxide (H2O2) in cancer cells. Recently, atmospheric pressure non-thermal plasma jet (APPJ) have been frequently used for cancer treatment through the generation of different kinds of ROS species. However, APPJ still has some demerits, such as durability after treatment. Hence, in this work, H2O vapour is applied as a synergetic agent to APPJ, which not only controls the temperature rise, but also enhances selectivity by increasing the level of H2O2 and OH radicals during treatment. We observed that due to the increased concentration of OH radicals, apoptosis was induced on SK-BR3 breast cancer cells through an enhancement of oxidative signalling, which inhibits the phosphorylation of extracellular signal-regulated kinases (Erks) and activates the phosphorylation of mintogen-activated protein kinases (p38-MAPK). Furthermore, we studied the DNA damage, and PARP-1 cleaved analysis from treated cancer cells. The results show that OH/H2O2 plays a pivotal role in not only inducing cell death but also in enhancing the selective killing effect.
机译：用于癌症治疗的新方法是基于羟基自由基（OH），并在癌细胞的过氧化氢（H2O2）的先天性生产过剩。最近，大气压非热等离子体射流（APPJ）已经被频繁通过不同种ROS物种的产生用于癌症治疗。然而，APPJ还是有一些缺点，如治疗后的耐用性。因此，在该工作中，H 2 O蒸汽被施加作为协同剂APPJ，它不仅控制的温度上升，而且通过在治疗过程中增加的H 2 O 2和OH自由基的水平提高了选择性。我们观察到，由于OH基浓度的增加，细胞凋亡是通过增强氧化信令，其抑制细胞外信号调节激酶（ERK）磷酸化诱导的SK-BR3乳腺癌细胞和激活的磷酸化mintogen活化蛋白激酶（P38-MAPK）。此外，我们研究了DNA损伤，并从处理过的癌细胞PARP-1裂解分析。结果表明，OH / H2O2起到不仅诱导细胞死亡，而且还增强了选择性杀伤作用举足轻重的作用。

著录项

  • 来源
    《RSC Advances》 |2015年第19期|共8页
  • 作者

    Kumar Naresh; Attri Pankaj; Choi Eun Ha; Uhm Han Sup;

  • 作者单位

    Kwangwoon Univ Plasma Biosci Res Ctr Dept Elect &

    Biol Phys Seoul 139701 South Korea;

    Kwangwoon Univ Plasma Biosci Res Ctr Dept Elect &

    Biol Phys Seoul 139701 South Korea;

    Kwangwoon Univ Plasma Biosci Res Ctr Dept Elect &

    Biol Phys Seoul 139701 South Korea;

    Kwangwoon Univ Plasma Biosci Res Ctr Dept Elect &

    Biol Phys Seoul 139701 South Korea;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号