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The effect of hemiketals on the relaxivity of endohedral gadofullerenols

机译：半塔对胚乳钆甘油烯醇松弛率的影响

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摘要

Gadofullerenols have received much attention due to their high relaxivities and low-toxicity as magnetic resonance imaging (MRI) contrast agents. However, the relaxivities of gadofullerenols vary in different reports. In this study, Gd@C-82(OH)(x)O-y with different hemiketal content were synthesized and the influence of this factor on water proton relaxation was investigated. The results show that Gd@C-82(OH)(x)O-y with more hemiketals exhibit much higher relaxivities than those with fewer hemiketals. The hemiketal structure is supposed to promote the formation of intermolecular hydrogen bonds, and finally lead to large aggregates. This is consistent with a previous report that the relaxivities of endohedral gadofullerene derivatives are strongly associated with the aggregate size. Hence, this work provides an important strategy for the manipulation of the relaxivities of gadofullerene based MRI contrast agents by controlling the quantity of hemiketals on the carbon cage.
机译：由于它们的高放松性和低毒性为磁共振成像（MRI）造影剂，Gadofullerenols非常关注。 然而，Gadofullerenols的松弛在不同的报告中变化。 在该研究中，综合了具有不同半碱含量的GD @ C-82（OH）（X）O-Y，研究了该因子对水质子松弛的影响。 结果表明，Gd @ C-82（OH）（x）O-y具有更多的半幂，比具有更少的半幂的轻松性高得多。 标记结构应该促进分子间氢键的形成，最终导致大聚集体。 这与先前的报告一致，即EndoheDral甘蛋白衍生物的松弛性与聚集体大有关。 因此，该作品通过控制碳笼上的半幂量来操纵基于碳酸环基的MRI造影剂的松弛性的重要策略。

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  • 来源
    《RSC Advances》 |2015年第117期|共5页
  • 作者

    Zou Toujun; Zhen Mingming; Li Jie; Chen Daiqin; Feng Yongqiang; Li Ruimin; Guan Mirong; Zhang Ying; Shu Chunying; Wang Chunru;

  • 作者单位

    Chinese Acad Sci Inst Chem Key Lab Mol Nanostruct &

    Nanotechnol Beijing Natl Lab Mol Sci Beijing 100190 Peoples R China;

    Chinese Acad Sci Inst Chem Key Lab Mol Nanostruct &

    Nanotechnol Beijing Natl Lab Mol Sci Beijing 100190 Peoples R China;

    Chinese Acad Sci Inst Chem Key Lab Mol Nanostruct &

    Nanotechnol Beijing Natl Lab Mol Sci Beijing 100190 Peoples R China;

    Chinese Acad Sci Inst Chem Key Lab Mol Nanostruct &

    Nanotechnol Beijing Natl Lab Mol Sci Beijing 100190 Peoples R China;

    Chinese Acad Sci Inst Chem Key Lab Mol Nanostruct &

    Nanotechnol Beijing Natl Lab Mol Sci Beijing 100190 Peoples R China;

    Chinese Acad Sci Inst Chem Key Lab Mol Nanostruct &

    Nanotechnol Beijing Natl Lab Mol Sci Beijing 100190 Peoples R China;

    Chinese Acad Sci Inst Chem Key Lab Mol Nanostruct &

    Nanotechnol Beijing Natl Lab Mol Sci Beijing 100190 Peoples R China;

    Chinese Acad Sci Inst Chem Key Lab Mol Nanostruct &

    Nanotechnol Beijing Natl Lab Mol Sci Beijing 100190 Peoples R China;

    Chinese Acad Sci Inst Chem Key Lab Mol Nanostruct &

    Nanotechnol Beijing Natl Lab Mol Sci Beijing 100190 Peoples R China;

    Chinese Acad Sci Inst Chem Key Lab Mol Nanostruct &

    Nanotechnol Beijing Natl Lab Mol Sci Beijing 100190 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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