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Highly selective and sensitive recognition of histidine based on the oxidase-like activity of Cu2+ ions

机译:基于Cu 2 +离子的氧化酶样活性对组织的高度选择性和敏感识别

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摘要

Developing simple, highly sensitive and selective sensing systems for histidine (His) is important due to its biological significance. In this report, Cu2+ ions serving as the oxidase mimics towards O-phenylenediamine (OPD) were investigated in detail. Experimental results revealed that the oxidase-like activity of Cu2+ ions is substantially higher than that of Cu/CuO nanoparticles. On the basis of these findings, a simple, highly sensitive and selective PL sensing platform for His could be developed, with a limit of detection (LOD) as low as 0.33 mu M. Furthermore, experiments of His recovery in human urine samples were successfully conducted by employing the established sensing system with satisfactory results.
机译:由于其生物学意义,为组氨酸(HIS)开发简单,高度敏感和选择性感测系统是重要的。 在本报告中,详细研究了用作氧化酶模拟物的Cu2 +离子被详细研究。详细研究了对O-苯二胺(OPD)。 实验结果表明,Cu 2 +离子的氧化酶样活性基本上高于Cu / CuO纳米颗粒的氧化酶样活性。 在这些发现的基础上,可以开发一种简单,高度敏感和选择性的PL传感平台,其检测极限(LOD)低至0.33μm。此外,他在人类尿液样本中的恢复实验成功了 通过采用既定的传感系统进行令人满意的结果进行。

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  • 来源
    《RSC Advances》 |2015年第112期|共7页
  • 作者单位

    Chinese Acad Sci Key Lab Urban Pollutant Convers Inst Urban Environm Xiamen 361021 Peoples R China;

    Chinese Acad Sci Key Lab Urban Pollutant Convers Inst Urban Environm Xiamen 361021 Peoples R China;

    Chinese Acad Sci Key Lab Urban Pollutant Convers Inst Urban Environm Xiamen 361021 Peoples R China;

    Chinese Acad Sci Key Lab Urban Pollutant Convers Inst Urban Environm Xiamen 361021 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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