• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >Understanding the pathway of antibacterial activity of copper oxide nanoparticles
【24h】

Understanding the pathway of antibacterial activity of copper oxide nanoparticles

机译：了解氧化铜纳米粒子抗菌活性的途径

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This work investigates the role of oxidation state in the antibacterial activity of copper oxide nanoparticles (NPs). The findings add strong support to a contact killing mechanism of copper oxides (CuO and Cu2O) through which bacteria initially suffer severe damage to the cell envelope. Then further damage ensues by an independent pathway of each copper oxide nanoparticle. Formation of copper(I)-peptide complex from cuprous oxide (Cu2O) and free radical generation from cupric oxide (CuO) were identified as key sources of toxicity towards E. coli. Cu2O rapidly inactivated Fumarase A, an iron sulphur cluster enzyme suggesting the cuprous state of copper binding to the proteins. This inactivation was not noticed in CuO. The percentage of biocidal/bacteriostatic activity is closely related to the oxidation state of the copper oxides. In the case of E. coli, Cu2O nanoparticles showed more efficient antibacterial activity and higher affinity to the bacterial cells. CuO nanoparticles produced significant ROS in terms of super oxides while Cu2O did not. The diminishing defective emission peaks of Cu2O after incubation with microbes strongly suggest the formation of protein complexes. This work is carried out to enable better understanding of the mechanistic pathways of copper oxide nanoparticles.
机译：该工作研究了氧化状态在氧化铜氧化物纳米颗粒（NPS）的抗菌活性中的作用。该发现增加了铜氧化铜（CuO和Cu2O）的接触杀伤机制，细菌最初对细胞包膜造成严重损害的接触杀伤机制。然后通过每种铜氧化物纳米颗粒的独立途径随之的损伤。从氧化亚铜（Cu2O）的铜（I）铜（I）的形成和从氧化铜（CuO）的自由基产生，被鉴定为对大肠杆菌的关键毒性源。 Cu2O迅速灭活的富马酶A，硫簇酶，表明铜与蛋白质结合的铜状状态。 CUO没有注意到这种失活。杀生物/抑菌活性的百分比与铜氧化物的氧化状态密切相关。在大肠杆菌的情况下，Cu2O纳米颗粒显示出更有效的抗菌活性和对细菌细胞的亲和力更高。 CuO纳米粒子在超氧化物方面产生了显着的RO，而CU2O没有。用微生物孵育后Cu2O的缺陷发射峰的缺陷发射峰强烈表明蛋白质复合物的形成。进行该工作以使得能够更好地理解氧化铜纳米颗粒的机械途径。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号