Spiroplakortone, an unprecedented spiroketal lactone from the Chinese sponge Plakortis simplex

Chianese Giuseppina; Gu Bin-Bin; Yang Fan; Jiao Wei-Hua; Guo Yue-Wei; Lin Hou-Wen; Taglialatela-Scafati Orazio

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Spiroplakortone, an unprecedented spiroketal lactone from the Chinese sponge Plakortis simplex

机译：Spiroploplakortone，来自中国海绵Plakortis Simplex的前所未有的刺激内酯

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A new polyketide-based metabolite, spiroplakortone (1), characterized as an unprecedented gamma-spiroketalg-lactone, was obtained from the Chinese sponge Plakortis simplex. Structural characterization of spiroplakortone (1) was based on extensive spectroscopic analysis and its configuration was partly established by GIAO C-13-NMR, supported by DP4 probability analysis, and ECD calculations. A plausible pathway for the biosynthesis of spiroplakortone (1), envisaging the formation of a carbon-carbon linkage between polyketide and aminoacid (leucine)-derived moieties, has been proposed.

机译：从中国海绵Plakortis Simplex中获得了一种新的基于聚酮基的代谢物（1），以前所未有的γ-spiroketalg-内酯获得。螺胶酮（1）的结构表征基于广泛的光谱分析，其构型由DP4概率分析和ECD计算的支持部分地建立了由GiaO C-13-NMR建立的。已经提出了一种可粘性肺状合金（1）的能量途径，设想形成聚酮和氨基酸（氨基酸（亮氨酸）之间的碳 - 碳键的形成。

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来源
《RSC Advances》 |2015年第78期|共5页
作者
Chianese Giuseppina; Gu Bin-Bin; Yang Fan; Jiao Wei-Hua; Guo Yue-Wei; Lin Hou-Wen; Taglialatela-Scafati Orazio;
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作者单位

Univ Naples Federico II Dipartimento Farm I-80131 Naples Italy;

Renji Hosp Sch Med State Key Lab Oncogenes &

Related Genes Key Lab Marine Drugs Dept Pharm Shanghai 200127 Peoples R China;

Renji Hosp Sch Med State Key Lab Oncogenes &

Related Genes Key Lab Marine Drugs Dept Pharm Shanghai 200127 Peoples R China;

Renji Hosp Sch Med State Key Lab Oncogenes &

Related Genes Key Lab Marine Drugs Dept Pharm Shanghai 200127 Peoples R China;

Chinese Acad Sci Shanghai Inst Mat Med State Key Lab Drug Res Shanghai 201203 Peoples R China;

Renji Hosp Sch Med State Key Lab Oncogenes &

Related Genes Key Lab Marine Drugs Dept Pharm Shanghai 200127 Peoples R China;

Univ Naples Federico II Dipartimento Farm I-80131 Naples Italy;

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正文语种 eng
中图分类化学;
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1. Spiroplakortone, an unprecedented spiroketal lactone from the Chinese sponge Plakortis simplex [J] . Chianese Giuseppina, Gu Bin-Bin, Yang Fan, RSC Advances . 2015,第78期

机译：Spiroploplakortone，来自中国海绵Plakortis Simplex的前所未有的刺激内酯
2. Metabolites From the Sponge Plakortis simplex. II. Isolation of Four Bioactive Lactone Compounds and of a Novel Related Amino Acid [J] . Francesco Cafieri, Ernesto Fattorusso, Orazio Taglialatela-Scafati, Tetrahedron . 1999,第48期

机译：海绵Plakortis单纯体的代谢产物。二。四种生物活性内酯化合物和一种新型相关氨基酸的分离
3. Cytotoxic Polyketide Derivatives from the South China Sea Sponge Plakortis simplex [J] . Zhang Jinrong, Tang Xuli, Li Jing, Journal of natural products . 2013,第4期

机译：南海海绵Plakortis simplex的细胞毒性聚酮化合物衍生物
4. Distribution and Abundance of Archaea in South China Sea Sponge Holoxea sp. and the Presence of Ammonia-Oxidizing Archaea in Sponge Cells [C] . Fang Liu, Minqi Han, Fengli Zhang, International Marine Biotechnology Conference . 2010

机译：南海海绵中的古细菌分布和丰富度Holoxea sp。和氨氧化古细菌在海绵细胞中的存在
5. Asymmetric total synthesis of bioactive cyclic peroxides from the marine sponge Plakortis angulospiculatus: Design and synthesis of orally available cisplatin analogs. [D] . Yao, Gang. 1999

机译：海洋海绵Prakortis angulospiculatus生物活性环状过氧化物的不对称总合成：口服顺铂类似物的设计和合成。
6. Woodylides A–C New Cytotoxic Linear Polyketides from the South China Sea Sponge Plakortis simplex [O] . Hao-Bing Yu, Xiang-Fang Liu, Ying Xu, 2012

机译：Woodylides A–C来自南海海绵Plakortis simplex的新型细胞毒性线性聚酮化合物
7. Woodylides A–C, New Cytotoxic Linear Polyketides from the South China Sea Sponge <em>Plakortis simplex</em> [O] . Hou-Wen Lin, Yang Shen, Xiang-Fang Liu, 2012

机译：Woodylides a-C，来自南海海绵的新细胞毒性线性聚酮化合物＆lt; em＆gt; plakortis simplex＆lt; / em＆gt;

Spiroplakortone, an unprecedented spiroketal lactone from the Chinese sponge Plakortis simplex

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