Synthesis and in vitro phantom NMR and MRI studies of fully organic free radicals, TEEPO-glucose and TEMPO-glucose, potential contrast agents for MRI

Soikkeli M.; Sievanen K.; Peltonen J.; Kaasalainen T.; Timonen M.; Heinonen P.; Ronkko S.; Lehto V. -P.; Kavakka J. S.; Heikkinen S.

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Synthesis and in vitro phantom NMR and MRI studies of fully organic free radicals, TEEPO-glucose and TEMPO-glucose, potential contrast agents for MRI

机译：完全有机自由基，螺旋状葡萄糖和凝固术，椎间盘糖和凝固性的合成和体外Phantom NMR和MRI研究，MRI的潜在造影剂

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Two organic radical contrast agents, TEMPO-Glc and TEEPO-Glc, were synthesized and their stabilities and contrast enhancing properties were tested with in vitro NMR and MRI experiments. Owing to the glucose moieties in the prepared compounds, this study presents potential candidates for a tumor targeting fully organic contrast agents for MRI.

机译：合成了两种有机自由基造影剂，Tempo-Glc和Teepo-Glc，并用体外NMR和MRI实验测试它们的稳定性和对比增强性能。由于制备的化合物中的葡萄糖部分，该研究为靶向MRI的完全有机造影剂靶向肿瘤的潜在候选者。

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来源
《RSC Advances》 |2015年第20期|共4页
作者
Soikkeli M.; Sievanen K.; Peltonen J.; Kaasalainen T.; Timonen M.; Heinonen P.; Ronkko S.; Lehto V. -P.; Kavakka J. S.; Heikkinen S.;
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Univ Helsinki Dept Chem Lab Organ Chem FIN-00014 Helsinki Finland;

Univ Helsinki Dept Chem Lab Organ Chem FIN-00014 Helsinki Finland;

HUS HUS Helsinki Med Imaging Ctr FIN-00029 Helsinki Finland;

HUS HUS Helsinki Med Imaging Ctr FIN-00029 Helsinki Finland;

HUS HUS Helsinki Med Imaging Ctr FIN-00029 Helsinki Finland;

Univ Helsinki Dept Chem Lab Organ Chem FIN-00014 Helsinki Finland;

Univ Eastern Finland Dept Appl Phys FIN-70211 Kuopio Finland;

Univ Eastern Finland Dept Appl Phys FIN-70211 Kuopio Finland;

Univ Helsinki Dept Chem Lab Organ Chem FIN-00014 Helsinki Finland;

Univ Helsinki Dept Chem Lab Organ Chem FIN-00014 Helsinki Finland;

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正文语种 eng
中图分类化学;
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1. Synthesis and in vitro phantom NMR and MRI studies of fully organic free radicals, TEEPO-glucose and TEMPO-glucose, potential contrast agents for MRI [J] . Soikkeli M., Sievanen K., Peltonen J., RSC Advances . 2015,第20期

机译：完全有机自由基，螺旋状葡萄糖和凝固术，椎间盘糖和凝固性的合成和体外Phantom NMR和MRI研究，MRI的潜在造影剂
2. Synthesis and in vitro studies of Gd-DTPA derivatives as new potential MRI contrast agents [J] . Arigala Uma Ravi Sankar, Mitsuji Yamasitha, Kambam Srinivasulu Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2010,第18期

机译：新型潜在的MRI造影剂Gd-DTPA衍生物的合成和体外研究
3. A Facile Synthesis, In vitro and In vivo MR Studies of D-Glucuronic Acid-Coated Ultrasmall Ln2o3 (Ln = Eu, Gd, Dy, Ho, and Er) Nanoparticles as a New Potential MRI Contrast Agent [J] . Krishna Kattel, Ja Young Park, Wenlong Xu ACS applied materials & interfaces . 2011,第9期

机译：D-葡萄糖醛酸涂层超小Ln2o3（Ln = Eu，Gd，Dy，Ho和Er）纳米粒子作为新型潜在MRI造影剂的简便合成，体外和体内MR研究
4. In Vitro and In Vivo Studies Glycosylated Gadolinum Nanomagnetic Particleas (GD-DTPA-DG) as New Potential Metabolic Contrast Agent in MMRI [C] . S. Heydarnezhadi, N. Riyahi-Alam, S. Haghgoo World Congress on Medical Physics and Biomedical Engineering . 2015

机译：体外和体内研究糖基化的钆纳米磁性蛋白酶（Gd-DTPA-DG）作为MMRI的新潜在代谢造影剂
5. NMR studies of I. Photodamaged DNA duplexes, II. Sodium concentrations in septic mouse and III. Two iron chelates as potential brain MRI contrast agents. [D] . Li, Wei. 2001

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Synthesis and in vitro phantom NMR and MRI studies of fully organic free radicals, TEEPO-glucose and TEMPO-glucose, potential contrast agents for MRI

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