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Influence of magnetic nanoparticle arrangement in ferrogels for tunable biomolecule diffusion

机译：磁性纳米粒子布置对可调谐生物分子扩散的影响

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摘要

Magnetic sensitive hydrogels (ferrogels) with tunable nanochannels were prepared with poly (vinyl alcohol) (PVA) and iron oxide magnetic nanoparticles under a uniform magnetic field in a freezing-thawing process, evaluated by differential scanning calorimetry (DSC), and the influence of magnetic nanoparticle arrangement on the diffusion behavior of biomolecules was investigated. Nanochannels self-assembled by the arranged magnetic nanoparticles could be tuned by manipulating the direction of the magnetic field, which results in the formation of “needle-like” structures from the magnetic nanoparticles aligned parallel or perpendicular to the permeation direction (anisotropic ferrogels). The effect of biomolecule diffusion between the anisotropic and isotropic ferrogels was observed in a diffusion diaphragm cell (using random nanoparticle dispersions without a magnetic field, as a control). It was established that the parallel-aligned ferrogels exhibit a higher drug diffusion rate compared to the isotropic ferrogels, whereas the perpendicular-aligned ferrogels display the lowest biomolecule diffusion rate. The novel ferrogels were expected to be suitable for application in bio-membranes, and the nanochannels for biomolecule (MW: ca. 0.1-10 kDa) diffusion could be constructed precisely by the magnetic nanoparticle arrangement.
机译：用聚（乙烯醇）（PVA）（PVA）和氧化铁磁性纳米粒子在冰冻扫描过程中的均匀磁场下制备具有可调谐纳米的磁性敏感水凝胶（Ferrogels），通过差示扫描量热法（DSC）进行评估，以及影响研究了生物分子扩散行为的磁性纳米粒子布置。通过布置的磁性纳米颗粒自组装的纳米可以通过操纵磁场的方向来调节，这导致从平行或垂直于渗透方向的磁性纳米颗粒（各向异性二甲丙烯）的磁性纳米颗粒形成“针状”结构。在扩散膜片细胞中观察到各向异性和各向同性二甲胶凝胶之间的生物分子扩散的影响（使用没有磁场的无随机纳米粒子分散体，作为对照）。建立了与各向同性二甲胶凝胶质相比，并联对准的卵石表现出更高的药物扩散速率，而垂直对齐的卵石率显示出最低的生物分子扩散速率。预计新型铁蛋镜适合于在生物膜中施用，并且可以精确地通过磁性纳米颗粒布置来构造生物分子（MW：Ca.0.1-10kDa）扩散的纳米烷基。

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  • 来源
    《RSC Advances》 |2015年第109期|共5页
  • 作者

    Ting-Yu Liu; Tzu-Yi Chan; Kuan-Syun Wang;

  • 作者单位

    Department of Materials Engineering Ming Chi University of Technology New Taipei City 24301 Taiwan.;

    Department of Materials Engineering Ming Chi University of Technology New Taipei City 24301 Taiwan.;

    Department of Materials Engineering Ming Chi University of Technology New Taipei City 24301 Taiwan.;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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