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首页> 外文期刊>RSC Advances >Synthesis and structure of new dicopper(II) complexes bridged by asymmetric N, N '-bis( substituted) oxamides: in vitro anticancer activity and molecular docking studies based on bio-macromolecular interaction
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Synthesis and structure of new dicopper(II) complexes bridged by asymmetric N, N '-bis( substituted) oxamides: in vitro anticancer activity and molecular docking studies based on bio-macromolecular interaction

机译：通过不对称N，N'-BIS（取代）氧化物桥接新的二泊（II）复合物的合成和结构：基于生物高分子相互作用的体外抗癌活性和分子对接研究

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摘要

Two new dicopper(II) complexes bridged by asymmetric N, N'-bis(substituted) oxamide ligands: N-(5-chloro- 2-hydroxyphenyl)-N'-[3-(2-hydroxyethylamino)propyl] oxamide (H(3)chpoxd) and N- (5-chloro-2-hydroxyphenyl)-N'-[(methylamino) propyl] oxamide (H(3)chmpoxd), and end-capped with 2,2'-bipyridine (bpy), namely [Cu-2(chpoxd)(H2O)(bpy)](NO3)center dot C2H5OH center dot H2O (1) and [Cu-2(chmpoxd)-(H2O)(bpy)]Cl center dot 3H(2)O (2), were synthesized and structurally characterized. The single-crystal X-ray diffraction analysis reveals that both the copper(II) ions in the two complexes are bridged by the cis-oxamido group, in which the exo-copper ions have square-pyramidal coordination geometries, while the inner ones are in a distorted square-pyramidal and a square-planar environment in complexes 1 and 2, respectively. The three dimensional supramolecular structures are constructed by hydrogen bonding and p-p stacking interactions. The reactivities towards DNA and protein BSA of the two complexes are studied both theoretically and experimentally. In vitro anticancer activities indicated that the two complexes are active against the selected tumor cell lines, and the anticancer activities are consistent with their DNA-binding affinities following the order 1 > 2.
机译：通过不对称N，N'-BIS（取代）氧酰胺配体桥接的两种新的双泊孔（II）配合物：N-（5-氯-2-羟基苯基）-N' - [3-（2-羟乙基氨基）丙基]氧酰胺（H. （3）CHPOXD）和N-（5-氯-2-羟基苯基）-N' - [（甲基氨基）丙基]氧酰胺（H（3）CHMPOXD），并用2,2'-硼吡啶（BPY）结束，即[Cu-2（CHPOXD）（H 2 O）（BPY）]（NO 3）中心点C2H5OH中心点H2O（1）和[CU-2（CHMPOXD） - （H2O）（BPY）] CL中心点3H（2 ）O（2），被合成并在结构上表征。单晶X射线衍射分析表明，两种配合物中的铜（II）离子均由顺式 - 氧基氨基组桥接，其中外铜离子具有方形锥形配位几何形状，而内部铜离子是在扭曲的方形金字塔和络合物1和2中的方形平面环境中。三维超分子结构由氢键和P-P堆叠相互作用构成。理论上和实验研究了两种复合物的DNA和蛋白质BSA的反应性。体外抗癌活性表明，两种络合物对所选择的肿瘤细胞系有活性，并且抗癌活性与顺序1> 2后的DNA结合亲和力一致。

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  • 来源
    《RSC Advances》 |2015年第64期|共15页
  • 作者

    Zheng Kang; Jiang Liu; Li Yan-Tuan; Wu Zhi-Yong; Yan Cui-Wei;

  • 作者单位

    Ocean Univ China Sch Med &

    Pharm Qingdao 266003 Peoples R China;

    Ocean Univ China Coll Food Sci &

    Engn Qingdao 266003 Peoples R China;

    Ocean Univ China Sch Med &

    Pharm Qingdao 266003 Peoples R China;

    Ocean Univ China Sch Med &

    Pharm Qingdao 266003 Peoples R China;

    Ocean Univ China Coll Marine Life Sci Qingdao 266003 Peoples R China;

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  • 中图分类 化学;
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