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Recent advances of curcumin and its analogues in breast cancer prevention and treatment

机译：姜黄素及其类似物在乳腺癌预防和治疗中的预期

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摘要

More than 230 000 diagnosed cases of invasive breast cancer in women were estimated in 2014 and an expected 40 000 deaths attributed to the aggressive carcinoma. An effective approach to diminish the morbidity and mortality of breast cancer is the development of chemopreventive and chemotherapeutic agents. Nutraceuticals have demonstrated their ability to proficiently halt carcinogenesis. The administration of natural compounds able to effectively serve as chemoprevention and chemotherapeutics without causing harm or adverse effects is imperative. Curcumin derived from the rhizome of Curcuma longa L., is a common spice of India, used for centuries because of its medicinal properties. The main component of curcumin possesses a wide range of biological activities; anti-proliferative, anti-inflammatory, and apoptotic characteristics modulated through the inactivation of pathways such as EGK and Akt/mTOR. In addition, curcumin alters the expression of cytokines, transcription factors, and enzymes involved in cell vitality. The in vivo application of curcumin in breast cancer is hindered by its limited bioavailability. The synthesis of curcumin analogues and delivery via nanoparticles has demonstrated enhanced bioavailability of curcumin in the malignancy. This review focuses on recent developments in the use of curcumin, curcumin analogues, and novel delivery systems as a preventive and therapeutic method for breast cancer.
机译：2014年估计了超过230 000例妇女侵袭性乳腺癌病例，预期的40 000人死亡归因于侵袭性癌。一种减少乳腺癌发病率和死亡率的有效方法是化学预防和化学治疗剂的发展。营养保健品证明了它们熟练暂停致癌的能力。施用能够有效用作化学预防和化学治疗剂而不会导致伤害或不利影响的天然化合物是必要的。源自莪术Longa L的根茎的姜黄素是印度的常见香料，因为其药用特性为几个世纪。姜黄素的主要成分具有广泛的生物活性;通过途径灭活（如EGK和AKT / MTOR）调节抗增殖性，抗炎和凋亡特征。此外，姜黄素会改变细胞因子，转录因子和参与细胞活力的酶的表达。通过其有限的生物利用度阻碍了姜黄素癌的体内应用。姜黄素类似物的合成和通过纳米颗粒的递送已经证明了恶性肿瘤中姜黄素的增强的生物利用度。本综述侧重于近期开发姜黄素，姜黄素类似物和新型递送系统作为乳腺癌预防和治疗方法。

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  • 来源
    《RSC Advances》 |2015年第92期|共14页
  • 作者

    Mock Charlotta D.; Jordan Brian C.; Selvam Chelliah;

  • 作者单位

    Texas So Univ Dept Pharmaceut Sci Coll Pharm &

    Hlth Sci Houston TX 77004 USA;

    Texas So Univ Dept Pharmaceut Sci Coll Pharm &

    Hlth Sci Houston TX 77004 USA;

    Texas So Univ Dept Pharmaceut Sci Coll Pharm &

    Hlth Sci Houston TX 77004 USA;

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  • 正文语种 eng
  • 中图分类 化学;
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