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Isolation of circulating tumour cells by physical means in a microfluidic device: a review

机译：微流体装置中物理手段分离循环肿瘤细胞：综述

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摘要

Isolation and enumeration of circulating tumour cells (CTCs) from human blood has a huge significance in diagnosis and prognosis of cancer. Utilization of the unique microscale flow phenomena called microfluidics offers ability to efficiently isolate CTCs from other haematological cells. The improvement in microfluidic technology allows time and cost efficient isolation of CTCs in a continuous manner utilising only up to nano-or micro-litres samples. This technology could potentially lead to the fabrication of cheap, disposable and transparent devices for sorting and molecular examination of even single cell. Additionally, the potential to physically entrap and capture rare CTCs in microfluidic devices can eliminate the need of expensive antibodies normally used for immune capturing of these rare cells which would further reduce the cost of operation. During the last few years, several innovative and intricate microfluidic designs to isolate and capture these extremely rare cells from the whole blood samples without using specific antibodies have been published. Herein, we review the recent literature on exploiting physical characteristics of tumour cells to efficiently isolate them from billion other cells and discuss the intricate design perspective of microfluidic devices for efficient in vitro cancer diagnosis and prognosis.
机译：人血管循环肿瘤细胞（CTC）的分离和计数在癌症的诊断和预后具有巨大意义。利用称为Microfluidics的独特微尺寸流现象提供了有效地将CTC与其他血液学细胞分离的能力。微流体技术的改善允许以连续的方式仅使用直到纳米或微升样品的连续方式和成本有效地分离CTC。该技术可能导致制造廉价，一次性和透明装置，用于分类和分子检查甚至单细胞。另外，物理诱捕和捕获微流体装置中稀有CTC的可能性可以消除通常用于免疫捕获这些稀有细胞的昂贵抗体的需要，这将进一步降低操作成本。在过去的几年中，一些创新和复杂的微流体设计，用于分离和捕获这些极稀有的细胞从整个血液样品而不使用特异性抗体。在此，我们审查了最近的文献，用于利用肿瘤细胞的物理特征，以有效地将其与百亿其他细胞分离，并讨论微流体装置的复杂设计视角，以高效的体外癌症诊断和预后。

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  • 来源
    《RSC Advances》 |2015年第109期|共18页
  • 作者

    Pravin Patil; Madhuprasad; Tushar Kumeria;

  • 作者单位

    Centre for Nano and Material Sciences Jain University Jain Global Campus Bangalore-562112 Karnataka India.;

    Centre for Nano and Material Sciences Jain University Jain Global Campus Bangalore-562112 Karnataka India.;

    School of Chemical Engineering University of Adelaide North Engineering Building Adelaide SA-5005 Australia;

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  • 正文语种 eng
  • 中图分类 化学;
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