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首页> 外文期刊>RSC Advances >Preparation and in vitro cell-biological performance of sodium alginate/nano-zinc silicate co-modified calcium silicate bioceramics
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Preparation and in vitro cell-biological performance of sodium alginate/nano-zinc silicate co-modified calcium silicate bioceramics

机译：藻酸钠/纳米锌硅酸钠共改性钙硅酸钙硅酸钠的制备及体外细胞生物学性能

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摘要

Sodium alginate/nano-zinc silicate (SA/nano-ZS) co-modified calcium silicate bioceramics (Na/Zn-CS) were prepared via the spin-coating process. X-ray diffraction patterns indicated the surface components of Na/Zn-CS disks were composed of calcium silicate (pseudowollastonite, CS), sodium calcium silicate and Na/Ca co-doped zinc silicate. Na/Zn-CS disks could induce hydroxyapatite to rapidly deposit on the surface of the disks after being soaked in simulated body fluid (SBF). The pH value of SBF, in which Na/Zn-CS disks were soaked, remained in a relatively low range, whereas that of SBF, in which pure CS disks were soaked, increased with the prolongation of soaking time. Whether rat bone marrow mesenchymal stem cells (rBMSCs) were co-cultured with CS disks or with Na/Zn-CS disks, the extracellular matrix mineralization of rBMSCs could be observed, which suggests the released silicon from the samples possesses osteoinductivity. F-actin staining images of rBMSCs revealed that the attachment and the spread of rBMSCs would not be influenced by the inorganic ions released from the samples, but by the interface stability of the cell/material. Furthermore, the surface dissolution rate significantly affected the initial proliferation of rBMSCs. After incubation for 14 days, the alkaline phosphatase (ALP) activity of rBMSCs cultured on the surface of the CS disk spin-coated with 0.1 g mL(-1) of SA/nano-ZS suspension (Na/0.1Zn-CS) was much higher than that of rBMSCs cultured on the surface of the pure CS disk, which indicates the released zinc ions can promote the differentiation of rBMSCs. In conclusion, the surface co-modification with SA/nano-ZS is an effective way to improve the dissolution behavior and biological performance of CS bioceramics.
机译：通过旋涂工艺制备藻酸钠/纳米锌硅酸钠（SA /纳米锌）共改性硅酸钙生物陶瓷（NA / ZN-CS）。 X射线衍射图案表明Na / Zn-CS盘的表面成分由硅酸钙（假旋属，Cs），硅酸钙钠和Na / Ca共掺杂硅酸钠组成。 Na / Zn-CS盘可以在浸泡在模拟体液（SBF）中诱导羟基磷灰石以在盘表面上迅速沉积。 SBF的pH值，其中浸泡Na / Zn-CS盘，仍然在相对较低的范围内，而SBF的浸渍在其中浸泡的SBF中，随着浸泡时间的延长而增加。是否将大鼠骨髓间充质干细胞（RBMSCs）与Cs盘或Na / Zn-CS盘共培养，可以观察到RBMSCs的细胞外基质矿化，这表明来自样品的释放硅具有骨诱导性。 RBMSC的F-Actin染色图像显示，RBMSCs的附着和扩散不会受到样品中释放的无机离子的影响，而是通过电池/材料的界面稳定性。此外，表面溶解速率显着影响了RBMSCs的初始增殖。孵育14天后，培养在CS盘表面上培养的RBMSC的碱性磷酸酶（ALP）活性旋转涂覆0.1g ml（-1）的SA /纳米-Zs悬浮液（NA / 0.1ZN-CS）远高于在纯CS盘表面上培养的RBMSCs的高得多，这表明释放的锌离子可以促进RBMSC的分化。总之，具有SA /纳米ZS的表面共同改性是改善CS生物陶瓷的溶出行为和生物学性能的有效方法。

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  • 来源
    《RSC Advances》 |2015年第11期|共11页
  • 作者

    Xiong Kun; Zhang Jing; Shi Haishan; Liu Jingqun; Wu Huae; Li Haiyan; Ye Jiandong;

  • 作者单位

    S China Univ Technol Sch Mat Sci &

    Engn Guangzhou 510640 Guangdong Peoples R China;

    S China Univ Technol Sch Mat Sci &

    Engn Guangzhou 510640 Guangdong Peoples R China;

    S China Univ Technol Sch Mat Sci &

    Engn Guangzhou 510640 Guangdong Peoples R China;

    S China Univ Technol Sch Mat Sci &

    Engn Guangzhou 510640 Guangdong Peoples R China;

    S China Univ Technol Sch Mat Sci &

    Engn Guangzhou 510640 Guangdong Peoples R China;

    S China Univ Technol Sch Mat Sci &

    Engn Guangzhou 510640 Guangdong Peoples R China;

    S China Univ Technol Sch Mat Sci &

    Engn Guangzhou 510640 Guangdong Peoples R China;

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