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Microfluidic fabrication of chitosan microfibers with controllable internals from tubular to peapod-like structures

机译：壳聚糖微纤维的微流体制造，具有来自管状的可控内部的微纤维，与Peapod的结构

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摘要

Here we report on a simple and flexible approach for continuous in situ fabrication of chitosan microfibers with controllable internals from tubular to peapod-like structures in microfluidics. Tubular and peapod-like jet templates can be generated at stable operation regions for template synthesis of chitosan microfibers with controllable tubular and peapod-like internals. The structure of each jet template can be precisely adjusted by simply changing the flow rates to tailor the structures of the resultant tubular and peapod-like chitosan microfibers. Both the tubular and peapod-like microfibers possess sufficient mechanical properties for further handling for biomedical applications. The tubular microfibers are used as biocompatible artificial vessels for transporting fluid, which is promising for delivering nutrition and blood for tissue engineering and cell culture. The peapod-like microfibers with controllable and separate oil cores can serve as multi-compartment systems for synergistic encapsulation of multiple drugs, showing great potential for developing drug-loaded medical patches for wound healing. The approach proposed in this study provides a facile and efficient strategy for controllable fabrication of microfibers with complex and well-tailored internals for biomedical applications.
机译：在这里，我们报告了一种简单而灵活的方法，用于壳聚糖微纤维的连续制造，该微纤维可控制内部，微流体中的孔板状结构。可以在稳定的操作区域中产生管状和孔保膜样射流模板，用于用可控管状和孔佩的内部构成壳聚糖微纤维的模板合成。通过简单地改变流速来定制所得管状和皮孔样壳聚糖微纤维的结构，可以精确地调节每个喷射模板的结构。管状和豌孔状微纤维均具有足够的机械性能以进一步处理生物医学应用。管状微纤维用作用于输送流体的生物相容性人工血管，这是对组织工程和细胞培养的营养和血液的承诺。具有可控和单独的油芯的孔保膜样微纤维可以用作多隔室系统，用于多种药物的协同封装，表明为伤口愈合发育载药的医学贴片的巨大潜力。本研究提出的方法提供了一种容易和有效的策略，可控制微纤维的制造，用于制造具有复杂和良好的生物医学应用内部的微纤维。

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  • 来源
    《RSC Advances》 |2015年第2期|共9页
  • 作者

    He Xiao-Heng; Wang Wei; Deng Ke; Xie Rui; Ju Xiao-Jie; Liu Zhuang; Chu Liang-Yin;

  • 作者单位

    Sichuan Univ Sch Chem Engn Chengdu 610065 Sichuan Peoples R China;

    Sichuan Univ Sch Chem Engn Chengdu 610065 Sichuan Peoples R China;

    Sichuan Univ Sch Chem Engn Chengdu 610065 Sichuan Peoples R China;

    Sichuan Univ Sch Chem Engn Chengdu 610065 Sichuan Peoples R China;

    Sichuan Univ Sch Chem Engn Chengdu 610065 Sichuan Peoples R China;

    Sichuan Univ Sch Chem Engn Chengdu 610065 Sichuan Peoples R China;

    Sichuan Univ Sch Chem Engn Chengdu 610065 Sichuan Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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