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Green synthesis of hyaluronic acid-based silver nanoparticles and their enhanced delivery to CD44(+) cancer cells

机译：透明质酸基银纳米粒子的绿色合成及其增强递送至CD44（+）癌细胞

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摘要

The potent antitumor activities of silver nanoparticles (AgNP) have attracted great attention. However, the application of AgNP is restricted by its non-specific delivery and poor cellular uptake. We developed a novel hyaluronic acid (HA)-based strategy for the green synthesis of AgNP, in which HA was used as the reducing agent and stabilizer. More importantly, HA is a ligand of CD44, and the HA-modified AgNP can target CD44 receptors that are overexpressed in many types of cancer cells. The CD44-dependent endocytosis can significantly increase the intracellular delivery of HA-AgNP, compared to the non-modified one. The antitumor efficacy was significantly improved by HA modification. Furthermore, we found that multiple mechanisms were involved for the enhanced anticancer activities of HA-AgNP, including the decline of mitochondrial membrane potential, cell-cycle arrest, apoptosis, and autophagy. The HA-based strategy for green synthesis and CD44-targeting delivery provided a promising solution for AgNP-mediated cancer treatment.
机译：银纳米粒子（AGNP）的有效抗肿瘤活性引起了极大的关注。然而，AGNP的应用受其非特异性递送和较差的细胞吸收的限制。我们开发了一种新的透明质酸（HA）基于AgNP的绿色合成的策略，其中HA被用作还原剂和稳定剂。更重要的是，HA是CD44的配体，HA-修饰的AgNP可以靶向许多类型的癌细胞中过表达的CD44受体。与未改性的，CD44依赖性内吞作用可以显着增加HA-AGNP的细胞内递送。通过HA改性显着提高了抗肿瘤功效。此外，我们发现多种机制参与了HA-AGNP的增强的抗癌活性，包括线粒体膜潜力，细胞周期骤停，细胞凋亡和自噬的下降。基于HA的绿色合成和CD44靶向递送的策略为AGNP介导的癌症治疗提供了有希望的解决方案。

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  • 来源
    《RSC Advances》 |2015年第54期|共8页
  • 作者

    Liang Jianming; Zeng Feng; Zhang Meng; Pan Zhenzhen; Chen Yingzhi; Zeng Yuaner; Xu Yong; Xu Qin; Huang Yongzhuo;

  • 作者单位

    Chinese Acad Sci Shanghai Inst Mat Med Shanghai 201203 Peoples R China;

    Chinese Acad Sci Shanghai Inst Mat Med Shanghai 201203 Peoples R China;

    Chinese Acad Sci Shanghai Inst Mat Med Shanghai 201203 Peoples R China;

    Chinese Acad Sci Shanghai Inst Mat Med Shanghai 201203 Peoples R China;

    Chinese Acad Sci Shanghai Inst Mat Med Shanghai 201203 Peoples R China;

    Guangzhou Univ Chinese Med Sch Chinese Mat Med Guangzhou 501450 Guangdong Peoples R China;

    Hubei Biol Med Ind Technol Inst Co Ltd Wuhan 430075 Peoples R China;

    Guangzhou Univ Chinese Med Inst Trop Med Guangzhou 501450 Guangdong Peoples R China;

    Chinese Acad Sci Shanghai Inst Mat Med Shanghai 201203 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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