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One-step facile synthesis of fluorescent gold nanoclusters for rapid bio-imaging of cancer cells and small animals

机译：荧光金纳米能量的一步容易合成，用于癌细胞和小动物的快速生物成像

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摘要

Fluorescent bio-imaging has become amajor topic of themodern biomedical research field. Fluorescent metal nanoclusters have been proposed as sensitive optical imaging probes aiming for early cancer diagnosis. We have developed a new strategy for the facile synthesis of Au-BSA nanoclusters (NCs) which have stable and bright fluorescence and could be used as a fluorescent probe for bioimaging rapidly and effectively. In this contribution, we have synthesized Au-BSA NCs at 80 degrees C for 10 minutes with the pH value of 11.5. At the concentration range of 0.1-10 mg mL(-1), Au-BSA NCs have no obvious cell cytotoxicity effect on MCF-7, HeLa, L02, U87, and A549 cells. Then the as-prepared Au-BSA NCs were characterized by using TEM and XPS and applied for rapid tumor imaging. The biocompatible BSA stabilized fluorescent gold nanoclusters (NCs) synthesized through one-step hydrothermal reaction possess strong and bright fluorescence that can be readily utilized as a highly sensitive fluorescence probe for tumor-targeted bio-imaging in vitro and in vivo.
机译：荧光生物成像已成为专题生物医学研究领域的Amajor主题。已经提出了荧光金属纳米团簇作为旨在早期癌症诊断的敏感光学成像探针。我们开发了一种新的荧光稳定且亮荧光的Au-BSA纳米能器（NCS）的新策略，并且可以用作快速且有效地用于生物成像的荧光探针。在这一贡献中，我们在80℃下合成了Au-BSA NCS 10分钟，pH值为11.5。在0.1-10mg ml（-1）的浓度范围内，Au-bsa ncs对MCF-7，Hela，L02，U87和A549细胞没有明显的细胞毒性作用。然后使用TEM和XPS来表征AS制备的AU-BSA NC并施用于快速肿瘤成像。通过一步水热反应合成的生物相容性BSA稳定的荧光金纳米纳米蛋白（NCS）具有强烈且明亮的荧光，其可以容易地用作高敏感的荧光探针，用于体外和体内肿瘤靶向生物成像。

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  • 来源
    《RSC Advances》 |2015年第78期|共6页
  • 作者

    Zhang Wanjun; Ye Jing; Zhang Yuanyuan; Li Qiwei; Dong Xiawei; Jiang Hui; Wang Xuemei;

  • 作者单位

    Southeast Univ Sch Biol Sci &

    Med Engn Chien Shiung Wu Lab State Key Lab Bioelect Nanjing 210096 Jiangsu Peoples R China;

    Southeast Univ Sch Biol Sci &

    Med Engn Chien Shiung Wu Lab State Key Lab Bioelect Nanjing 210096 Jiangsu Peoples R China;

    Southeast Univ Sch Biol Sci &

    Med Engn Chien Shiung Wu Lab State Key Lab Bioelect Nanjing 210096 Jiangsu Peoples R China;

    Southeast Univ Sch Biol Sci &

    Med Engn Chien Shiung Wu Lab State Key Lab Bioelect Nanjing 210096 Jiangsu Peoples R China;

    Southeast Univ Sch Biol Sci &

    Med Engn Chien Shiung Wu Lab State Key Lab Bioelect Nanjing 210096 Jiangsu Peoples R China;

    Southeast Univ Sch Biol Sci &

    Med Engn Chien Shiung Wu Lab State Key Lab Bioelect Nanjing 210096 Jiangsu Peoples R China;

    Southeast Univ Sch Biol Sci &

    Med Engn Chien Shiung Wu Lab State Key Lab Bioelect Nanjing 210096 Jiangsu Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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