Construction of nanoparticles based on amphiphilic PEI-PA polymers for bortezomib and paclitaxel co-delivery

Zhang Ruirui; Liu Yinghua; Yang Zhiwei; Li Yunhao; Rong Xianghui; Wang Lin; Guo Chujun; Li Sheng; Liu Junxing; Li Mingjun; Wu Yan

首页> 外文期刊>RSC Advances >Construction of nanoparticles based on amphiphilic PEI-PA polymers for bortezomib and paclitaxel co-delivery

【24h】

Construction of nanoparticles based on amphiphilic PEI-PA polymers for bortezomib and paclitaxel co-delivery

机译：基于两亲纤维PA聚合物的纳米粒子施工硼吡啶和紫杉醇共同递送

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Co-delivery is a feasible means to overcome the drawbacks of using a single drug. Herein, we report novel polymer nanoparticles based on branched polyethyleneimine and palmitic acid conjugates for bortezomib and paclitaxel co-delivery. These drug-loaded nanoparticles have a preferable particle size, high encapsulation efficiency and a pH-dependent release profile. The co-delivery system has a great advantage in suppressing tumor cell growth over single drug loaded nanoparticles, whereas the polymer nanocarrier itself shows excellent biocompatibility. The good cellular uptake properties and synergistic effects of co-delivery by polymer nanoparticles provide significant advances toward cancer therapy.

机译：共同交付是一种可行的方法，用于克服使用单一药物的缺点。这里，我们报告基于支化聚乙烯亚胺和棕榈酸缀合物的新型聚合物纳米粒子，用于硼替佐米和紫杉醇共递送。这些药物负载的纳米颗粒具有优选的粒度，高封装效率和pH依赖性释放曲线。共递送系统在抑制单一药物负载纳米颗粒上抑制肿瘤细胞生长具有很大的优势，而聚合物纳米载体本身呈现出优异的生物相容性。通过聚合物纳米粒子共同递送的良好细胞摄取性能和协同作用为癌症治疗提供了显着进展。

著录项

来源
《RSC Advances》 |2015年第20期|共8页
作者
Zhang Ruirui; Liu Yinghua; Yang Zhiwei; Li Yunhao; Rong Xianghui; Wang Lin; Guo Chujun; Li Sheng; Liu Junxing; Li Mingjun; Wu Yan;
展开▼
作者单位

Natl Ctr Nanosci &

Technol Lab Nanobiomed &

Nanosafety Div Nanomed &

Nanobiol Beijing 100190 Peoples R China;

Natl Ctr Nanosci &

Technol Lab Nanobiomed &

Nanosafety Div Nanomed &

Nanobiol Beijing 100190 Peoples R China;

Jiamusi Univ Sch Basic Med Sci Jiamusi 154007 Peoples R China;

Sun Yat Sen Univ Zhongshan Sch Med Dept Clin Med Guangzhou 510080 Guangdong Peoples R China;

Jiamusi Univ Sch Basic Med Sci Jiamusi 154007 Peoples R China;

Jiamusi Univ Sch Basic Med Sci Jiamusi 154007 Peoples R China;

Jiamusi Univ Sch Basic Med Sci Jiamusi 154007 Peoples R China;

Jiamusi Univ Sch Basic Med Sci Jiamusi 154007 Peoples R China;

Jiamusi Univ Sch Basic Med Sci Jiamusi 154007 Peoples R China;

Jiamusi Univ Sch Basic Med Sci Jiamusi 154007 Peoples R China;

Natl Ctr Nanosci &

Technol Lab Nanobiomed &

Nanosafety Div Nanomed &

Nanobiol Beijing 100190 Peoples R China;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类化学;
关键词

相似文献

外文文献
中文文献
专利

1. Construction of nanoparticles based on amphiphilic PEI-PA polymers for bortezomib and paclitaxel co-delivery [J] . Zhang Ruirui, Liu Yinghua, Yang Zhiwei, RSC Advances . 2015,第20期

机译：基于两亲纤维PA聚合物的纳米粒子施工硼吡啶和紫杉醇共同递送
2. Hemocompatibility of folic-acid-conjugated amphiphilic PEG-PLGA copolymer nanoparticles for co-delivery of cisplatin and paclitaxel: treatment effects for non-small-cell lung cancer [J] . He Zelai, Shi Zengfang, Sun Wenjie, Tumour biology : . 2016,第6期

机译：叶酸结合的两亲性PEG-PLGA共聚物纳米颗粒的血液相容性：顺铂和紫杉醇的共同给药：对非小细胞肺癌的治疗效果
3. Enhanced anti-tumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy PEG-PLGA copolymer nanoparticles. [J] . Wang H, Zhao Y, Wu Y, Biomaterials . 2011,第32期

机译：通过将阿霉素和紫杉醇与两亲性甲氧基PEG-PLGA共聚物纳米颗粒共输送来增强抗肿瘤功效。
4. Synergistic Effects in Suppressing Cancer Cell Survival and Proliferation by Co-Delivery of TRAIL and Paclitaxel Using Micellar Polymer Nanoparticles [C] . Ashlvnn L.Z. Lee, Y.Wang, S. Pervaiz, 23rd European conference on biomaterials 2010 . 2010

机译：通过胶束聚合物纳米粒子共同递送TRAIL和紫杉醇抑制癌细胞的存活和增殖的协同效应。
5. Cost-Benefit Analysis of Nanoparticle Albumin-Bound Paclitaxel versus Solvent-Based Paclitaxel for the Treatment of Metastatic Breast Cancer in the United States [D] . Vichansavakul, Kittaya 2013

机译：纳米白蛋白结合紫杉醇与溶剂型紫杉醇在美国治疗转移性乳腺癌的成本效益分析
6. Co-delivery of cisplatin and paclitaxel by folic acid conjugated amphiphilic PEG-PLGA copolymer nanoparticles for the treatment of non-small lung cancer [O] . Zelai He, Jingwen Huang, Yuanyuan Xu, 2015

机译：叶酸共轭两亲性PEG-PLGA共聚物纳米粒子共递送顺铂和紫杉醇用于治疗非小细胞肺癌
7. Polyethylenimine-functionalized silver nanoparticle-based co-delivery of paclitaxel to induce HepG2 cell apoptosis [O] . Yinghua Li, Min Guo, Zhengfang Lin, 2016

机译：聚乙烯亚胺官能化银纳米粒子的紫杉醇共递送，诱导Hepg2细胞凋亡
8. Platform Approach to Produce Polymer Nanoparticles with Modular Functionality from Amphiphilic Block Copolymer Stabilizers. [R] . Killops, K. L., Rodriguez, C., Lynd, N. A. 2014

机译：两亲性嵌段共聚物稳定剂生产具有模块化功能的聚合物纳米粒子的平台方法。

Construction of nanoparticles based on amphiphilic PEI-PA polymers for bortezomib and paclitaxel co-delivery

摘要

著录项

相似文献

相关主题

期刊订阅