• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >Preparation of keratin/chlorhexidine complex nanoparticles for long-term and dual stimuli-responsive release
【24h】

Preparation of keratin/chlorhexidine complex nanoparticles for long-term and dual stimuli-responsive release

机译：长期和双刺激释放角蛋白/氯己定复合纳米粒子的制备

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Nanoscale polyion complex formation via the electrostatic complexation of a polyelectrolyte and a charged drug is the most convenient method for building a drug delivery system that simultaneously realizes the carrier preparation and drug embedding. Herein, we prepared keratin/chlorhexidine complex nanoparticles (KCNPs) based on a drug-induced ionic gelation technique without using a crosslinker, organic solvent or surfactant. These KCNPs exhibited good stability even after having been long-standing for 14 days. The KCNPs were characterized using FTIR, DLS, SEM and TEM. It was found that these nanoparticles had a spherical morphology with a diameter of about 180 nm, and a negatively charged surface with a zeta potential of about -39.1 mV. The cell toxicity of the KCNPs at different dosage levels was evaluated using the MTT assay method, indicating their slight cytotoxicity at lower dosages. The antibacterial activity against E. coli and S. aureus was determined using the zone of inhibition method. It seemed that the KCNPs had better antibacterial activity against S. aureus than against E. coli. Drug delivery profiles showed that the chlorhexidine (CHX) loaded nanoparticles exhibited both pH- and glutathione-responsive character. These keratin-based complex nanoparticles can be regarded as a valuable stimuli-responsive strategy for the delivery of anticancer agents.
机译：通过聚电解质的静电络合和带电药物的纳米级聚硫末络合物形成是建立药物递送系统的最方便的方法，该系统同时实现载体制剂和药物嵌入。在此，我们在不使用交联剂，有机溶剂或表面活性剂的情况下制备基于药物诱导的离子凝胶化技术的角蛋白/氯己定复合纳米颗粒（KCNP）。即使在长期14天后，这些KCNP也表现出良好的稳定性。使用FTIR，DLS，SEM和TEM表征KCNP。发现这些纳米颗粒具有直径为约180nm的球形形态，以及带负电的表面，Zeta电位为约-39.1mV。使用MTT测定法评估KCNP在不同剂量水平下的细胞毒性，表明它们在较低剂量下的细胞毒性。使用抑制法测定针对大肠杆菌和金黄色葡萄球菌的抗菌活性。似乎KCNPS对金黄色葡萄球菌具有更好的抗菌活性而不是对大肠杆菌。药物递送曲线显示氯己定（CHX）纳米颗粒表现出pH-和谷胱甘肽响应性的特征。这些基于角蛋白的复合纳米颗粒可以被认为是用于递送抗癌剂的有价值的刺激响应策略。

著录项

  • 来源
    《RSC Advances》 |2015年第100期|共8页
  • 作者

    Zhi Xuelian; Wang Yanfang; Li Pengfei; Yuan Jiang; Shen Jian;

  • 作者单位

    Nanjing Normal Univ Coll Chem &

    Mat Sci Jiangsu Key Lab Biofunct Mat Nanjing 210023 Jiangsu Peoples R China;

    Nanjing Normal Univ Coll Chem &

    Mat Sci Jiangsu Key Lab Biofunct Mat Nanjing 210023 Jiangsu Peoples R China;

    Nanjing Normal Univ Coll Chem &

    Mat Sci Jiangsu Key Lab Biofunct Mat Nanjing 210023 Jiangsu Peoples R China;

    Nanjing Normal Univ Coll Chem &

    Mat Sci Jiangsu Key Lab Biofunct Mat Nanjing 210023 Jiangsu Peoples R China;

    Nanjing Normal Univ Coll Chem &

    Mat Sci Jiangsu Key Lab Biofunct Mat Nanjing 210023 Jiangsu Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号