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Fabrication of cationized gelatin nanofibers by electrospinning for tissue regeneration

机译：通过静电纺丝组织再生的阳离子化明胶纳米纤维的制备

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摘要

Gelatin based electrospun nanofibers are promising candidates for tissue engineering and regenerative medicine due to properties like biocompatibility, non antigenicity, non-toxicity and structural resemblance with native extracellular matrix. In the present work, a new nanofibrous scaffold using amine functionalized gelatin is fabricated. Modified gelatin is also known by the name cationized gelatin as the amino group is getting protonated. Unlike gelatin, the cationized gelatin is soluble in water without forming gel at room temperature. Hence, electrospinning of cationized gelatin can be carried out using water as the solvent. The water stability of cationized gelatin nanofibers is improved by crosslinking with two novel cross-linking agents, namely a disaccharide (sucrose) and a polysaccharide (dextran). The resulting cationized gelatin nanofibers are evaluated for the mouse fibroblast and human osteoblast like cells attachment, adhesion and proliferation. The results demonstrate that the electrospun cationized gelatin nanofibers can be potential scaffold materials for tissue regenerations.
机译：基于明胶基电梭纳面纤维是组织工程和再生医学的候选者，由于生物相容性，非抗原性，非毒性和与天然细胞外基质的结构相似性等性质。在本作工作中，制造了一种使用胺官能化明胶的新的纳米纤维支架。由于氨基被质子化，所修饰的明胶也是已知的阳离子化明胶。与明胶不同，阳离子化明胶可溶于水而不在室温下形成凝胶。因此，可以使用作为溶剂的水进行阳离子化明胶的静电纺丝。通过用两种新型交联剂交联，改善了阳离子化明胶纳米纤维的水稳定性，即二糖（蔗糖）和多糖（葡聚糖）。评价所得阳离子化明胶纳面纤维，用于小鼠成纤维细胞和人成骨细胞，如细胞附着，粘附和增殖。结果表明，电纺阳离子明胶纳米纤维可以是用于组织再生的潜在支架材料。

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  • 来源
    《RSC Advances》 |2015年第109期|共10页
  • 作者

    Jalaja K; Deboki Naskar; Subhas C. Kundu;

  • 作者单位

    Department of Chemistry Indian Institute of Space Science and Technology Thiruvananthapuram-695 547 India.;

    Department of Biotechnology Indian Institute of Technology Kharagpur West Bengal-721302 India;

    Department of Biotechnology Indian Institute of Technology Kharagpur West Bengal-721302 India;

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  • 正文语种 eng
  • 中图分类 化学;
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