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首页> 外文期刊>RSC Advances >Characterization and evaluation of curcumin loaded guar gum/polyhydroxyalkanoates blend films for wound healing applications
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Characterization and evaluation of curcumin loaded guar gum/polyhydroxyalkanoates blend films for wound healing applications

机译：姜黄素负荷瓜尔胶/聚羟基烷酸盐混合膜的表征及评价伤口愈合应用

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摘要

The present paper explores the 'in situ' fabrication of guar gum/polyhydroxyalkanoates-curcumin blend (GPCC) films in view of their increasing applications as wound dressings and antibacterial materials. Curcumin is incorporated to assess its bactericidal activity and to enhance the production and accumulation of the extracellular matrix in the healing process. In order to characterize the nature of the polymer network in the blend, FTIR/ATR spectra analysis and TGA are performed. The results reveal that the rigidity of the guar gum/PHBV blend improves with the increase of PHBV content due to the formation of non-covalent interactions, especially H-bonds, between these molecules. Electron microscopy analyses reveal the homogenecity of the blends and surface roughness of the blended films, favoring cell attachment and cell proliferation compared with the film without curcumin. The antimicrobial study demonstrate that the bactericidal activity is more effective against Gram-positive strains than Gram-negative strains. Results of the in vivo wound healing study in an animal model demonstrates that the developed curcumin loaded guar gum/PHBV blend film shows markedly enhanced wound healing compared to the control one.
机译：本文探讨了瓜尔胶/多羟基烷烃 - 姜黄素共混物（GPCC）薄膜的“原位”制作，鉴于其增加的应用作为伤口敷料和抗菌材料。掺入姜黄素以评估其杀菌活性，并增强细胞外基质在愈合过程中的产生和积累。为了表征共混物中的聚合物网络的性质，进行FTIR / ATR光谱分析和TGA。结果表明，由于非共价相互作用，尤其是H键之间，瓜尔胶/ pHBV混合物的刚性随着PHBV含量的增加而改善了这些分子之间的非共价相互作用。电子显微镜分析揭示了混合膜的混合物和表面粗糙度的均匀性，与没有姜黄素的薄膜相比，有利于细胞附着和细胞增殖。抗微生物研究表明，杀菌活性比革兰氏阴性菌株更有效。动物模型中体内伤口愈合研究的结果表明，与对照相比，发育的姜黄素负载的瓜尔胶口/ PHBV共混膜显示出明显增强的伤口愈合。

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  • 来源
    《RSC Advances》 |2015年第78期|共13页
  • 作者

    Pramanik Nilkamal; Mitra Tapas; Khamrai Moumita; Bhattacharyya Aditi; Mukhopadhyay Piyasi; Gnanamani A.; Basu Ranjan Kumar; Kundu Patit Paban;

  • 作者单位

    Univ Calcutta Dept Polymer Sci &

    Technol Adv Polymer Lab Kolkata 700009 India;

    Univ Calcutta Dept Polymer Sci &

    Technol Adv Polymer Lab Kolkata 700009 India;

    Univ Calcutta Dept Polymer Sci &

    Technol Adv Polymer Lab Kolkata 700009 India;

    Univ Calcutta Dept Polymer Sci &

    Technol Adv Polymer Lab Kolkata 700009 India;

    Univ Calcutta Dept Polymer Sci &

    Technol Adv Polymer Lab Kolkata 700009 India;

    Cent Leather Res Inst Dept Biol Sci Madras 600020 Tamil Nadu India;

    Univ Calcutta Dept Chem Engn Kolkata 700009 India;

    Univ Calcutta Dept Polymer Sci &

    Technol Adv Polymer Lab Kolkata 700009 India;

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  • 正文语种 eng
  • 中图分类 化学;
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