• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >A microfluidic approach for flexible and efficient operation of a cross-coupling reactive flow
【24h】

A microfluidic approach for flexible and efficient operation of a cross-coupling reactive flow

机译：一种微流体方法，可灵活，有效地运行交叉耦合反应流动

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In this work, a flexible and efficient flow microreactor has been developed for the synthesis of an aromatic amine via a Buchwald-Hartwig reaction, a key bond-forming reaction in the synthesis of a wide range of naturally-occurring and pharmaceutically active targets. The microreactor, coupled with a highly active palladium N-heterocyclic carbene (NHC) catalyst, enabled the full conversion of the reagents within twenty minutes, even at very low catalyst concentrations. In addition to the classical two-feed design, a novel, more flexible four-feed flow system was developed with a configuration optimised to avoid clogging, which is one of the main problems in microreactors and in continuous flow reactive systems in general. We report the effect of flow rate, temperature and catalyst loading on conversion degree. In particular, a slight increase in temperature allowed faster conversion even at low catalyst loadings, likely due to the highly efficient heat transfer provided by the confined microreactor geometry.
机译：在这项工作中，通过Buchwald-Hartwig反应开发了一种柔性高效的流动微反应器，用于合成芳香胺，在合成各种天然存在和药物活性靶标中的关键键合反应。与高活性钯N-杂环碳切苯（NHC）催化剂偶联的微反应器使得即使在非常低的催化剂浓度下也能够在20分钟内全转化试剂。除了经典的两进料设计外，一种新颖的，更灵活的四进给流系统是通过优化的配置而开发的，以避免堵塞，这是微反应器和连续流动反应系统中的主要问题之一。我们报告了流速，温度和催化剂负载对转化程度的影响。特别地，即使在低催化剂载量，均匀的温度均匀升高，可能由于受限微反应器几何形状提供的高效热传递，这可能甚至更快地转化。

著录项

  • 来源
    《RSC Advances》 |2015年第78期|共7页
  • 作者

    Perazzo A.; Tomaiuolo G.; Sicignano L.; Toscano G.; Meadows R. E.; Nolan S. P.; Guido S.;

  • 作者单位

    Univ Naples Federico II Dipartimento Ingn Chim Mat &

    Prod Ind I-80125 Naples Italy;

    Univ Naples Federico II Dipartimento Ingn Chim Mat &

    Prod Ind I-80125 Naples Italy;

    Univ Naples Federico II Dipartimento Ingn Chim Mat &

    Prod Ind I-80125 Naples Italy;

    Univ Naples Federico II Dipartimento Ingn Chim Mat &

    Prod Ind I-80125 Naples Italy;

    AstraZeneca Pharmaceut Dev Macclesfield SK10 2NA Cheshire England;

    Univ St Andrews EaStCHEM Sch Chem St Andrews KY16 9ST Fife Scotland;

    Univ Naples Federico II Dipartimento Ingn Chim Mat &

    Prod Ind I-80125 Naples Italy;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号