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首页> 外文期刊>RSC Advances >Adsorption and sustained release of haemoglobin imprinted polysiloxane using a calcium alginate film as a matrix
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Adsorption and sustained release of haemoglobin imprinted polysiloxane using a calcium alginate film as a matrix

机译：使用钙藻酸钙膜作为基质的吸附和持续释放血红蛋白被印迹聚硅氧烷

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摘要

A calcium alginate (CA) hydrogel film was prepared by cross-linking sodium alginate (SA) with a CaCl2 solution. Haemoglobin (Hb) molecularly imprinted polysiloxane (MIP) was synthesized using silane as a functional monomer, Hb as a template and a CA hydrogel film as a matrix. SEM, TEM, TG and a water contact angle test were used to characterize the CA hydrogel and MIP film. The adsorption and recognition properties of MIPs were evaluated and the results showed that the MIP exhibited a significant improvement in terms of rebinding capacity for Hb compared with non-imprinted polysiloxane (NIP). Haemoglobin imprinted polysiloxane could selectively recognize the template protein from a mixture of other competitive proteins. The surface hydrophilicity and the swelling behaviour of the MIP film can be adjusted by changing the ratio of two types of silane. Hb was released from the MIP in a sustained manner in PBS and Tris-HCl solutions. The Higuchi model fits best for the MIP film no matter whether it is in PBS or in a Tris-HCl solution. It is a diffusion-controlled release mechanism for the MIP film. But diffusion is not the key factor for release of the NIP film.
机译：通过用CaCl 2溶液交联藻酸钠（SA）制备藻酸钙（CA）水凝胶膜。使用硅烷作为官能单体，Hb作为模板和Ca水凝胶膜作为基质合成血红蛋白（Hb）分子印迹聚硅氧烷（MIP）。 SEM，TEM，Tg和水接触角试验用于表征Ca水凝胶和覆膜膜。评估MIP的吸附和识别性质，结果表明，与非印记聚硅氧烷（NIP）相比，MIP对Hb的折衷能力显着改善。血红蛋白被印迹聚硅氧烷可以从其他竞争性蛋白质的混合物中选择性地识别模板蛋白。通过改变两种硅烷的比例，可以调节覆膜膜的表面亲水性和溶胀行为。 HB以PBS和Tris-HCl溶液中的持续方式从MIP释放。无论是在PBS还是在TRIS-HCl溶液中，HIGUCHI模型最适合MIP薄膜。它是壁膜的扩散控制释放机构。但扩散不是释放凝胶膜的关键因素。

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  • 来源
    《RSC Advances》 |2015年第34期|共8页
  • 作者

    Zhu Dunwan; Chen Zhuo; Zhao Kongyin; Kan Bohong; Li Hui; Zhang Xinxin; Lin Beibei; Zhang Linhua;

  • 作者单位

    Chinese Acad Med Sci Inst Biomed Engn Tianjin 300192 Peoples R China;

    Chinese Acad Med Sci Inst Biomed Engn Tianjin 300192 Peoples R China;

    Tianjin Polytech Univ State Key Lab Hollow Fiber Film Mat &

    Proc Tianjin 300387 Peoples R China;

    Tianjin Univ Tradit Chinese Med Teaching Hosp 1 Tianjin 300193 Peoples R China;

    Tianjin Polytech Univ State Key Lab Hollow Fiber Film Mat &

    Proc Tianjin 300387 Peoples R China;

    Tianjin Polytech Univ State Key Lab Hollow Fiber Film Mat &

    Proc Tianjin 300387 Peoples R China;

    Tianjin Polytech Univ State Key Lab Hollow Fiber Film Mat &

    Proc Tianjin 300387 Peoples R China;

    Chinese Acad Med Sci Inst Biomed Engn Tianjin 300192 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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