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Nanostructure and cytotoxicity of self-assembled monoolein-capric acid lyotropic liquid crystalline nanoparticles

机译：自组装单烯醇己酸层升液晶纳米粒子的纳米结构和细胞毒性

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摘要

Monoolein forms self-assembled nanoparticles with various internally ordered nanostructures, including the lyotropic liquid crystalline inverse hexagonal and inverse bicontinuous cubic phases. This study investigated the influence of a saturated fatty acid, capric acid (decanoic acid), on the formation of different lyotropic liquid crystalline phases in monoolein-based systems. The nanoparticles were characterized by synchrotron small angle X-ray scattering (SAXS), cryogenic transmission electron microscopy (cryo-TEM), dynamic light scattering, and zeta potential measurements. The addition of capric acid to monoolein triggered concentration dependent phase changes with the sequence evolving from an inverse primitive cubic phase to inverse double-diamond cubic, inverse hexagonal (H-vertical bar vertical bar), and emulsified microemulsions. SAXS and cryo-TEM revealed the formation of both single phase and mixed phases within a nanoparticle. To understand the cytotoxicity effects of the different nanoparticles, cellular cytotoxicity and hemolysis assays were performed. Nanoparticles in emulsion and hexagonal phases were found to be less toxic than cubic phase nanoparticles. The hemolysis assays followed the same trend with cubic phase dispersions causing the highest level of hemoglobin release. In summary, this study showed that the internal lyotropic liquid crystal mesophase structure of self-assembled nanoparticles needs careful consideration in the design of drug delivery vehicles.
机译：单烯醇素形成具有各种内部有序纳米结构的自组装纳米颗粒，包括旋转液晶逆六方六角形和逆双周三阶段。本研究研究了饱和脂肪酸，癸酸（癸酸）的影响，对基于单烯醇的体系中不同的旋转液晶晶相的形成。该纳米颗粒的特征在于同步角度小角度X射线散射（SAX），低温透射电子显微镜（Cryo-TEM），动态光散射和Zeta电位测量。向MonoOlein触发浓度依赖性相变相变化，从逆基引导立方相变化到反相双金刚石立方，逆六边形（H-垂直条垂直棒）和乳化微乳液的序列。 SAXS和Cryo-TEM显示在纳米颗粒内形成单相和混合相。为了了解不同纳米颗粒的细胞毒性作用，进行细胞细胞毒性和溶血测定。发现乳液和六边形相中的纳米颗粒比立方相纳米颗粒少于毒性。溶血测定遵循与立方相分散体相同的趋势，导致最高水平的血红蛋白释放。总之，这项研究表明，自组装纳米粒子的内部喉液晶中间相结构需要仔细考虑药物递送载体的设计。

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