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首页> 外文期刊>RSC Advances >Low temperature and deformation-free bonding of PMMA microfluidic devices with stable hydrophilicity via oxygen plasma treatment and PVA coating
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Low temperature and deformation-free bonding of PMMA microfluidic devices with stable hydrophilicity via oxygen plasma treatment and PVA coating

机译：PMMA微流体装置的低温和无变形键合，通过氧等离子体处理和PVA涂层具有稳定的亲水性

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摘要

In the present study, a low temperature and deformation-free bonding method to seal hydrophilicity-stable microchannels in polymethyl methacrylate (PMMA) microfluidic devices was proposed. Oxygen plasma pre-/post-treatments and polyvinyl alcohol (PVA) coating were performed on the PMMA microfluidic substrates before thermal bonding. Different surface treatments were characterized using a confocal profilometer, tensiometer, attenuated total reflection Fourier-transform infrared spectrometer (ATR-FTIR), differential scanning calorimeter (DSC), and scanning electron microscope (SEM). The effects of surface modification on bond strength and microchannel integrity were studied. Oxygen plasma treatment prior to PVA coating was found to be significant in improving the coating uniformity and enhancing the adhesion between the PVA layer and the PMMA base. The PMMA microchannel substrate could be bonded to a homogeneous PMMA cover plate at about 70 degrees C (30 degrees C lower than the PMMA glass transition temperature, T-g) with the coated PVA layer serving as a medium material which had high wettability, high surface energy and low Tg. With oxygen plasma post-treatment of the coated PVA layer, the bond strength was improved and comparable to that obtained by pure thermal bonding at a temperature near the T-g of PMMA. Due to the low bonding temperature, the microchannel integrity was well retained with negligible deformation. The hydrophilicity stability of different surface treatments was evaluated and compared under both dry and wet storage conditions for a month. The results suggested that the PVA-coated PMMA substrates with oxygen plasma post-treatment present the highest hydrophilicity and lowest hydrophobic recovery. As a demonstration, monodispersed oil-in-water (O/W) droplets with volumes of sub-10 nL were successfully and reliably generated in the hydrophilic microfluidic devices fabricated with the proposed bonding method.
机译：在本研究中，提出了一种在聚甲基丙烯酸甲酯（PMMA）微流体装置中密封亲水性稳定的微通道的低温和无变形的键合方法。在热粘合之前在PMMA微流体基板上进行氧等离子体和聚乙烯醇（PVA）涂层。使用相辅相仪，张力计，减振的全反射傅里叶变换红外光谱仪（ATR-FTIR），差示扫描量热计（DSC）和扫描电子显微镜（SEM）的不同表面处理。研究了表面改性对粘合强度和微通道完整性的影响。发现PVA涂层之前的氧等离子体处理在改善涂层均匀性并增强PVA层和PMMA底座之间的粘附性方面是显着的。 PMMA微通道基板可以在约70℃（低于PMMA玻璃化转变温度，Tg）的均匀PMMA盖板上用用作具有高润湿性，高表面能的介质材料的涂覆的PVA层粘合到均匀的PMMA盖板上。和低TG。利用氧等离子体处理涂覆的PVA层后处理，改善粘合强度并与通过在PMMA的T-G的温度下通过纯热键合而获得的粘合强度。由于粘接温度低，微通道完整性良好地保持不足的变形。评估不同表面处理的亲水性稳定性，并在干燥和湿储存条件下进行一个月。结果表明，具有氧等离子体后处理的PVA涂覆的PMMA底物具有最高的亲水性和最低疏水性回收率。作为示范，在用所提出的粘接方法制造的亲水性微流体装置中成功且可靠地产生单分散的水 - 水（O / W）液滴，其具有亚10 N1的体积。

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  • 来源
    《RSC Advances》 |2015年第11期|共12页
  • 作者

    Yu H.; Chong Z. Z.; Tor S. B.; Liu E.; Loh N. H.;

  • 作者单位

    Nanyang Technol Univ Sch Mech &

    Aerosp Engn Singapore 639798 Singapore;

    Nanyang Technol Univ Sch Mech &

    Aerosp Engn Singapore 639798 Singapore;

    Nanyang Technol Univ Sch Mech &

    Aerosp Engn Singapore 639798 Singapore;

    Nanyang Technol Univ Sch Mech &

    Aerosp Engn Singapore 639798 Singapore;

    Nanyang Technol Univ Sch Mech &

    Aerosp Engn Singapore 639798 Singapore;

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  • 中图分类 化学;
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