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Layer-by-layer self-assembled thin films of chitin fibers and heparin with anti-thrombus characteristics

机译：逐层甲壳素纤维和肝素的层自组装薄膜，具有抗血栓特性

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摘要

Anti-thrombus coatings using natural polymers with high biocompatibility were successfully fabricated by a Layer-by-Layer (LbL) method. The cationic and anionic components were chitin nanofibers and heparin, respectively. LbL multilayers were successfully fabricated by depositing different numbers of bilayers. Analyzing the damping waves of Quartz Crystal Microbalance (QCM) measurements showed that the film hardened as the number of bilayers deposited increased. Mass change measurements via QCM, scanning electron microscopy, atomic force microscopy, ellipsometry, and X-ray photoelectron spectroscopy were also carried out. The density of the chitin nanofiber layers increased as the number of bilayers increased. Simultaneously, the film stability in solution improved. The fabricated 30-bilayer film showed a fibrous structure on its surface and no structural disorder, even after 48 hours immersion in phosphate buffered saline (PBS), so high stability in PBS was demonstrated. The anti-thrombus properties of the film were also investigated by measuring the amount of fibrinogen adsorbed using QCM. This film not only inhibits fibrinogen adsorption, but those fibrinogen which do adsorb detach relatively easily (compared with fibrinogen adsorbed onto an uncoated QCM substrate). Furthermore, while the uncoated glass substrate adsorbed a large quantity of blood on its surface, the 30-bilayer coated glass substrate successfully inhibited blood adsorption and blood solidification.
机译：使用具有高生物相容性的天然聚合物的抗血栓涂层通过层逐层（LBL）方法成功制造。阳离子和阴离子组分分别是几丁质纳米纤维和肝素。通过沉积不同数量的双层成功制造LBL多层。分析石英晶体微稳压（QCM）测量的阻尼波显示，随着沉积的双层数量增加而变硬。还通过QCM，扫描电子显微镜，原子力显微镜，椭圆形和X射线光电子能谱进行质量变化测量。随着双层的数量增加，几丁质纳米纤维层的密度增加。同时，溶液中的膜稳定性改善。所制造的30-双层薄膜显示出在其表面和没有结构紊乱上的纤维结构体，即使经过在磷酸盐缓冲盐水（PBS）48小时浸没，在PBS中这样高的稳定性证明。还通过测量使用QCM吸附的纤维蛋白原的量来研究膜的抗血栓性质。该薄膜不仅抑制纤维蛋白原吸附，而且纤维蛋白原相对容易脱离（与吸附在未涂覆的QCM底物上的纤维蛋白原）相对脱落）。此外，在未涂覆的玻璃基板上吸附其表面上大量的血液，而30-双层涂覆的玻璃基板成功抑制血液吸附和血液凝固。

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  • 来源
    《RSC Advances》 |2015年第130期|共9页
  • 作者

    Taniguchi Taihei; Kyung Kyu-Hong; Shiratori Seimei;

  • 作者单位

    Keio Univ Grad Sch Sci Tech Kohoku Ku Yokohama Kanagawa 223 Japan;

    Keio Univ Grad Sch Sci Tech Kohoku Ku Yokohama Kanagawa 223 Japan;

    Keio Univ Grad Sch Sci Tech Kohoku Ku Yokohama Kanagawa 223 Japan;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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