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Fabrication of mono-dispersed silica-coated quantum dot-assembled magnetic nanoparticles

机译:单分散二氧化硅涂层量子点组装磁性纳米粒子的制备

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摘要

Multifunctional nanoparticles (NPs) with magnetic and luminescent properties have garnered considerable attention in various fields of biomedical and physiological applications. In this study, we report the fabrication of QD-embedded silica NPs with an iron oxide NP core (Fe3O4@SiO2@QDs NPs) that has dual functional properties. The Fe3O4@SiO2@QDs NPs were mono-dispersed in size and exhibited superparamagnetic and highly fluorescent properties. Most of the Fe3O4@SiO2@QDs NPs were naturally internalized into MDA-MB-231 human breast cancer cells, and the NP containing cells were successfully sorted by utilizing both fluorescence flow cytometry and a magnetic field. Results indicate that the Fe3O4@SiO2@QDs NPs have great potential for multimodal cell separation.
机译:具有磁性和发光性能的多功能纳米颗粒(NPS)在生物医学和生理应用领域的各个领域已经获得了相当大的关注。 在这项研究中,我们报告了QD嵌入式二氧化硅NP与具有双功能性质的氧化铁NP芯(Fe3O4 @ SiO 2 @ QDS NPS)的制备。 FE3O4 @ SiO2 @ QDS NPS尺寸单分散,表现出超顺磁性和高荧光特性。 大多数Fe3O4 @ SiO 2 @ SiO 2 @QDS NPS自然内化为MDA-MB-231人乳腺癌细胞,通过利用荧光流式细胞术和磁场来成功地分选NP细胞。 结果表明FE3O4 @ SiO2 @ QDS NPS具有很大的多模式细胞分离的潜力。

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  • 来源
    《RSC Advances》 |2015年第41期|共6页
  • 作者单位

    Seoul Natl Univ Sch Chem &

    Biol Engn Seoul 151747 South Korea;

    Seoul Natl Univ Sch Chem &

    Biol Engn Seoul 151747 South Korea;

    Seoul Natl Univ Coll Med Dept Nucl Med Seoul 110744 South Korea;

    Seoul Natl Univ Coll Med Dept Nucl Med Seoul 110744 South Korea;

    Seoul Natl Univ Dept Elect Engn &

    Comp Sci Seoul 151747 South Korea;

    Seoul Natl Univ Sch Chem &

    Biol Engn Seoul 151747 South Korea;

    Seoul Natl Univ Coll Med Dept Nucl Med Seoul 110744 South Korea;

    Konkuk Univ Dept Biosci &

    Biotechnol Seoul 143701 South Korea;

    Seoul Natl Univ Sch Chem &

    Biol Engn Seoul 151747 South Korea;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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