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Synthesis of amphiphilic fluorescent PEGylated AIE nanoparticles via RAFT polymerization and their cell imaging applications

机译：通过筏聚合及其细胞成像应用合成两亲荧光聚乙二醇化AIE纳米粒子

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摘要

With the increasing interest in the use of luminescent probes in biomedical applications, the development of fluorescent organic nanoparticles (FONs) on the basis of aggregation induced emission (AIE) dyes has attracted great research attention. In this study, a polymerizable tetraphenylethene-functionalized AIE dye (named as TPEV) with a vinyl end functional group was synthesized by a “one-step” Suzuki coupling reaction of 4-vinylphenylboronic acid and bromotriphenylethylene, and the as-prepared hydrophobic AIE dye TPEV subsequently participated in the reversible addition-fragmentation chain transfer (RAFT) polymerization together with the hydrophilic monomer of poly(ethylene glycol) monomethacrylate (PEGMA) to obtain a new amphiphilic copolymer (denoted as TPEV-PEG) with transformed side fluorescent groups. The Mn value of the obtained copolymer was about 29 800 g mol~1 with a narrow polydispersity index (PDI) of about 1.30. The molar ratio of TPE to PEG segment in the copolymer was respectively about 19.2% to 80.8%, and it was easy for the TPEV-PEG copolymer to self-assemble into FONs with the hydrophobic AIE core encapsulated by a hydrophilic PEG shell. The research results further showed that the TPEV-PEG FONs presented good fluorescent features with the maximal emission peak at 480 nm, high dispersibility in water solution with homogeneous spherical morphology (200 nm) and excellent biocompatibility, giving them good potential for bioimaging applications.
机译：随着在生物医学应用中使用发光探针的兴趣日益较大，荧光有机纳米颗粒（FONS）的发展基于聚集诱导的发射（AIE）染料引起了巨大的研究人身。在该研究中，通过4-乙烯基苯基硼酸和溴噻吩基亚乙烯的“一步”铃木偶联反应合成了具有乙烯基末端官能团的可聚合的四苯基乙烯官能化AIE染料（命名为TPEV），并制备的疏水性AIE染料TPEV随后参与可逆添加 - 碎片链转移（筏）聚合，与聚（乙二醇）单甲基甲酸酯（PEGMA）的亲水性单体一起，得到具有转化侧荧光基的新的两亲共聚物（表示为TPEV-PEG）。所得共聚物的Mn值约为29 800g mol〜1，具有约1.30的窄多分散指数（PDI）。 TPE在共聚物中的TPE与PEG段的摩尔比分别为约19.2％至80.8％，并且TPEV-PEG共聚物容易用疏水性PEG壳包封的疏水性AIE核自动组装成FOCE。研究结果进一步表明，TPEV-PEG FOCE呈现出良好的荧光特征，其具有480nm的最大排放峰值，水溶液中具有均匀球形形态（200nm）和优异的生物相容性，使其具有良好的生物分析应用潜力。

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  • 来源
    《RSC Advances》 |2015年第109期|共6页
  • 作者

    Zengfang Huang; Xiqi Zhang; Xiaoyong Zhang;

  • 作者单位

    College of Chemistry and Biology Zhongshan Institute University of Electronic Science &

    Technology of China Zhongshan 528402 P. R. China.;

    Department of Chemistry the Tsinghua Center for Frontier Polymer Research Tsinghua University Beijing 100084 P. R. China.;

    Department of Chemistry the Tsinghua Center for Frontier Polymer Research Tsinghua University Beijing 100084 P. R. China.;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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