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Structure-property relationships of antibacterial amphiphilic polymers derived from 2-aminoethyl acrylate

机译：衍生自2-氨基乙基丙烯酸酯的抗菌两亲聚合物的结构 - 性质关系

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摘要

The findings from the investigation of an ensemble of amphiphilic polymers derived from 2-aminoethyl acrylate establish significant effects of variation in the topographical position of the cationic center and hydrophobic segments on their biological activities. For example, the isomeric polymer pair of poly(6-aminohexylacrylate) and poly(2-(butylamino) ethyl acrylate) show striking differences in their biological activities, with the former having biological activities orders of magnitude higher. The trend of the activities of alkyl tails attached to the charge center shows an abrupt increase in biological activity at butyl length in the series of methyl to butyl tail. The distribution and interaction of the charge center in the chain domain is one of the main parameters in influencing polymer activities. Within the 2-aminoethyl acrylate system of homo- and copolymer, the homopolymer has its cationic centers closely distributed along the amphiphilic macromolecular chain with proximity to the backbone leading to rigid conformations not conducive to the attachment of the polymer to the cell surface. In copolymers, the incorporation of uncharged counits increases the distance between the cationic centers, resulting in significant reduction of charge repulsion and thus enhancing the flexibility of the chain conformation. This is conducive for polymer-cell association, leading to a remarkable surge in orders of magnitude of biological activity but with low selectivity against bacteria over red blood cells.
机译：从研究衍生自2-氨基乙基丙烯酸酯的两亲聚合物的研究的研究结果建立了阳离子中心和疏水区段的地形位置变化对其生物活性的显着影响。例如，异构聚合物对聚（6-氨基己酯）和聚（2-（丁基氨基）乙基丙烯酸酯）在其生物活性方面显示出显微差异，前者具有更高的生物活性的生物活性。附着在电荷中心的烷基尾部的活性的趋势在丁基尾巴的一系列甲基中突然在丁基长度下的生物活性增加。链域中的电荷中心的分布和相互作用是影响聚合物活性的主要参数之一。在均聚物和共聚物的2-氨基乙基丙烯酸酯体系中，均聚物的阳离子中心沿两亲的大分子链密切地分布，接近骨架，导致不利于聚合物对细胞表面的刚性构象的刚性构象。在共聚物中，未充电群的融合增加了阳离子中心之间的距离，导致电荷排斥的显着降低，从而提高了链构象的灵活性。这有利于聚合物 - 细胞联合，导致生物活性级的令人显着的浪涌，但对红细胞的细菌选择性低。

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  • 来源
    《RSC Advances》 |2015年第115期|共7页
  • 作者

    Punia Ashish; Debata Priya R.; Banerjee Probal; Yang Nan-Loh;

  • 作者单位

    CUNY Ctr Engn Polymer Mat New York NY 10021 USA;

    CUNY Coll Staten Isl Ctr Dev Neurosci New York NY 10021 USA;

    CUNY Coll Staten Isl Ctr Dev Neurosci New York NY 10021 USA;

    CUNY Ctr Engn Polymer Mat New York NY 10021 USA;

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  • 正文语种 eng
  • 中图分类 化学;
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