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首页> 外文期刊>RSC Advances >Preparation of an ascorbic acid/PVA-chitosan electrospun mat: a core/shell transdermal delivery system
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Preparation of an ascorbic acid/PVA-chitosan electrospun mat: a core/shell transdermal delivery system

机译：抗坏血酸/ PVA-壳聚糖电纺垫的制备：核心/壳透皮递送系统

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摘要

Core/shell L-ascorbic acid/poly(vinyl alcohol)-chitosan (ASC/PVA-CS) nanofibers were successfully prepared utilizing coaxial electrospinning and their characteristics were compared with monolithic blend PVA-CS-ASC nanofibers. In coaxial electrospinning, a series of aqueous acetic acid solutions of PVA-CS were used as a shell solution and a variety of ASC concentrations in a stabilizing solvent (ethanol/propylene glycol/water) were utilized as a core solution. Characterization of the obtained nanofibers was followed by SEM and TEM. Results of the SEM showed that an increase in PVA concentration in the shell solution or ASC concentration in the core solution increases the average diameter of nanofibers and leads to smooth morphologies. Furthermore, coaxial architecture of nanofibers was investigated and confirmed by differential thermal analysis (DTA) and X-ray diffraction (XRD). A release study indicated that a higher concentration of CS in the shell part of the crosslinked coaxial nanofibers leads to a decreased release rate of the ASC. Also, a lower concentration of ASC in the core part decreases the drug release from the core/shell nanofibers.
机译：利用同轴静电纺丝成功制备核/壳L-抗坏血酸/聚（乙烯醇）纳米纤维，并将其特性与单片混合物PVA-CS-ASC纳米纤维进行比较。在同轴电纺丝中，使用一系列PVA-CS的乙酸溶液作为壳溶液，稳定溶剂中的各种ASC浓度（乙醇/丙二醇/水）用作核心溶液。然后将所得纳米纤维的表征均进行SEM和TEM。 SEM的结果表明，壳溶液中的PVA浓度增加或核心溶液中的ASC浓度增加，增加了纳米纤维的平均直径，并导致平滑的形态。此外，通过差分热分析（DTA）和X射线衍射（XRD）来研究并确认纳米纤维的同轴结构。释放研究表明，交联同轴纳米纤维的壳体部分中的较高浓度的Cs导致ASC的释放速率降低。而且，芯部中的较低浓度的ASC浓度降低了从芯/壳纳米纤维中释放的药物释放。

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  • 来源
    《RSC Advances》 |2015年第62期|共8页
  • 作者

    Najafi-Taher Roqiye; Derakhshan Mohammad Ali; Faridi-Majidi Reza; Amani Amir;

  • 作者单位

    Univ Tehran Med Sci Sch Adv Technol Med Dept Med Nanotechnol Tehran 1417755469 Iran;

    Univ Tehran Med Sci Sch Adv Technol Med Dept Med Nanotechnol Tehran 1417755469 Iran;

    Univ Tehran Med Sci Sch Adv Technol Med Dept Med Nanotechnol Tehran 1417755469 Iran;

    Univ Tehran Med Sci Sch Adv Technol Med Dept Med Nanotechnol Tehran 1417755469 Iran;

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  • 正文语种 eng
  • 中图分类 化学;
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