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Absorption-dependent generation of singlet oxygen from gold bipyramids excited under low power density

机译：在低功率密度下励磁的金双氮杂物的吸收依赖性渗透

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摘要

Metal nanoparticles (MNPs) can be used as a kind of new photodynamic therapy (PDT) agent because singlet oxygen (O-1(2)) can be generated through directly sensitizing MNPs. Gold nanorods, gold nanoshells and gold nanoechinus were confirmed to be efficient PDT agents in vivo. However, the major excitation spectra of O-1(2) from all of them are not in the optical biological window (650-900 nm). Herein, gold bipyramids (GBPs) with tunable absorption wavelength were prepared and used to explore O-1(2) generation capability. O-1(2) can be generated when GBPs were excited by continuous-wave light within a wide range of wavelengths (660-975 nm). The highest O-1(2) generation capabilities were obtained when they were excited at the wavelength of the absorption peak, which was quite different from those of other gold nanomaterials. It was also found that O-1(2) can be generated efficiently by a laser of very low power density (200 mW cm(-2)). The capability of GBPs for PDT has been demonstrated through the destruction of cancer cells. The synergistic effect of PDT and photothermal therapy for the destruction of cancer cells was also demonstrated.
机译：金属纳米颗粒（MNP）可用作一种新的光动力治疗（PDT）代理，因为通过直接敏化MNP，可以通过直接敏感MNP来产生单线氧（O-1（2））。确认金纳米棒，金纳米孔和金纳米丝氨酸是体内有效的PDT药剂。然而，来自所有这些的O-1（2）的主要激发光谱不在光学生物窗口（650-900nm）中。在此，制备具有可调谐吸收波长的金与可调节吸收波长的金属酰胺（Gbps）并用于探索O-1（2）的产生能力。当通过在宽范围波长（660-975nm）的连续波光激发Gbps时，可以产生O-1（2）。当在吸收峰的波长在吸收峰的波长激发时获得最高的O-1（2）生成能力，这与其他金纳米材料的波长不同。还发现可以通过非常低功率密度的激光（200mW cm（-2））有效地产生O-1（2）。通过破坏癌细胞，已经证明了GBPS的GBP能力。还证明了PDT和光热疗治疗癌细胞破坏的协同效应。

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  • 来源
    《RSC Advances》 |2015年第100期|共8页
  • 作者

    Lv Junliang; Zhang Xin; Li Nana; Wang Baoju; He Sailing;

  • 作者单位

    S China Normal Univ S China Acad Adv Optoelect SCNU ZJU Joint Res Ctr Photon Ctr Opt &

    Electromagnet Res Guangzhou 510006 Guangdong Peoples R China;

    S China Normal Univ S China Acad Adv Optoelect SCNU ZJU Joint Res Ctr Photon Ctr Opt &

    Electromagnet Res Guangzhou 510006 Guangdong Peoples R China;

    S China Normal Univ S China Acad Adv Optoelect SCNU ZJU Joint Res Ctr Photon Ctr Opt &

    Electromagnet Res Guangzhou 510006 Guangdong Peoples R China;

    S China Normal Univ S China Acad Adv Optoelect SCNU ZJU Joint Res Ctr Photon Ctr Opt &

    Electromagnet Res Guangzhou 510006 Guangdong Peoples R China;

    S China Normal Univ S China Acad Adv Optoelect SCNU ZJU Joint Res Ctr Photon Ctr Opt &

    Electromagnet Res Guangzhou 510006 Guangdong Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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